PMID- 24013944
OWN - NLM
STAT- MEDLINE
DCOM- 20140213
LR  - 20211021
IS  - 1534-6315 (Electronic)
IS  - 1529-7322 (Linking)
VI  - 13
IP  - 6
DP  - 2013 Dec
TI  - Molecular basis for downregulation of C5a-mediated inflammation by IgG1 immune 
      complexes in allergy and asthma.
PG  - 596-606
LID - 10.1007/s11882-013-0387-3 [doi]
AB  - Allergy and asthma are triggered primarily by the binding of allergen-specific 
      immunoglobulin E (IgE)-allergen complexes to their receptors, recognition of the 
      allergens by antigen-presenting cells, and allergen presentation to the T cells. 
      These events lead to mucus secretions, runny nose, itchy eyes, sneezing, airway 
      hyperresponsiveness, and nasal congestion. Complement 5a (C5a) has emerged as a 
      central molecule that mediates these allergic reactions. Many allergens and 
      allergen-specific IgG immune complexes (IgG-ICs) cause complement activation and 
      C5a generation. C5a interaction with its receptor (C5aR) leads to the 
      infiltration and activation of several immunologic cell types and the secretion 
      of pathogenic inflammatory and proinflammatory mediators. However, IgG1-IC 
      binding to the IgG inhibitory Fc gamma receptor (FcgammaRIIB) suppresses 
      C5aR-mediated inflammatory signaling and, hence, may reduce the inflammatory 
      immune responses through this FcgammaRIIB-mediated pathway. Reviews of the IgG1-IC 
      interactions with C5a-mediated inflammatory immune responses suggest that 
      IgG1-IC-C5a inhibitory therapy may reduce inflammation in allergic diseases.
FAU - Pandey, Manoj Kumar
AU  - Pandey MK
AD  - Division of Human Genetics Cincinnati Children's Hospital Medical Center, Suite 
      R-1007, MLC 7016, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA, 
      Manoj.Pandey@cchmc.org.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Allergy Asthma Rep
JT  - Current allergy and asthma reports
JID - 101096440
RN  - 0 (Antigen-Antibody Complex)
RN  - 0 (Immunoglobulin G)
RN  - 80295-54-1 (Complement C5a)
SB  - IM
MH  - Animals
MH  - *Antigen-Antibody Complex
MH  - Asthma/genetics/*immunology
MH  - Complement C5a/*immunology
MH  - Down-Regulation
MH  - Humans
MH  - Hypersensitivity/*immunology
MH  - Immunoglobulin G/*immunology
EDAT- 2013/09/10 06:00
MHDA- 2014/02/14 06:00
CRDT- 2013/09/10 06:00
PHST- 2013/09/10 06:00 [entrez]
PHST- 2013/09/10 06:00 [pubmed]
PHST- 2014/02/14 06:00 [medline]
AID - 10.1007/s11882-013-0387-3 [doi]
PST - ppublish
SO  - Curr Allergy Asthma Rep. 2013 Dec;13(6):596-606. doi: 10.1007/s11882-013-0387-3.