PMID- 24014096
OWN - NLM
STAT- MEDLINE
DCOM- 20140919
LR  - 20220129
IS  - 1531-8257 (Electronic)
IS  - 0885-3185 (Linking)
VI  - 29
IP  - 1
DP  - 2014 Jan
TI  - N-methyl-D-aspartate receptor antibodies in post-herpes simplex virus 
      encephalitis neurological relapse.
PG  - 90-6
LID - 10.1002/mds.25626 [doi]
AB  - Herpes simplex virus encephalitis (HSVE) is a devastating condition that 
      relapses, often with a chorea in children, despite adequate antiviral treatment. 
      At relapse, evidence of viral replication is frequently absent, suggesting that 
      the relapse may be immune-mediated. Seven children who had a neurological relapse 
      following their initial encephalitis, identified from 20 cases of pediatric HSVE, 
      were studied. Serum and/or cerebrospinal fluid (CSF) were tested for 
      N-methyl-D-aspartate receptor (NMDAR) and other antibodies previously reported in 
      central nervous system autoimmunity. Five of the 7 relapsing children had 
      choreoathetosis; 2 of these were NMDAR antibody-positive, 2 were negative (1 with 
      HSV-positive CSF), and 1 was not available for testing. An additional patient, 
      who relapsed with cognitive regression but with no movement disorder, was also 
      NMDAR antibody-positive. In 2 of the NMDAR antibody-positive patients who were 
      treated at relapse and in 1 who was treated only after 10 years of having a 
      relapsing encephalopathy, a beneficial response was observed. Neurological 
      relapses after HSVE may frequently be immune-mediated, particularly in children 
      with chorea. NMDAR antibodies are common, and immunotherapy may be beneficial.
CI  - Copyright (c) 2013 Movement Disorder Society.
FAU - Hacohen, Yael
AU  - Hacohen Y
AD  - Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, 
      University of Oxford, Oxford, United Kingdom.
FAU - Deiva, Kumaran
AU  - Deiva K
FAU - Pettingill, Phillipa
AU  - Pettingill P
FAU - Waters, Patrick
AU  - Waters P
FAU - Siddiqui, Ata
AU  - Siddiqui A
FAU - Chretien, Pascale
AU  - Chretien P
FAU - Menson, Esse
AU  - Menson E
FAU - Lin, Jean-Pierre
AU  - Lin JP
FAU - Tardieu, Marc
AU  - Tardieu M
FAU - Vincent, Angela
AU  - Vincent A
FAU - Lim, Ming J
AU  - Lim MJ
LA  - eng
GR  - G0501898/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130906
PL  - United States
TA  - Mov Disord
JT  - Movement disorders : official journal of the Movement Disorder Society
JID - 8610688
RN  - 0 (Autoantibodies)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Adolescent
MH  - Anti-N-Methyl-D-Aspartate Receptor Encephalitis/blood/*immunology
MH  - Autoantibodies/*blood
MH  - Child, Preschool
MH  - Encephalitis, Herpes Simplex/blood/*immunology
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Receptors, N-Methyl-D-Aspartate/*immunology
MH  - Recurrence
OTO - NOTNLM
OT  - N-methyl-D-aspartate (NMDA) receptor
OT  - choreoathetosis
OT  - encephalitis
OT  - herpes simplex virus
OT  - movement disorder
OT  - relapsing
EDAT- 2013/09/10 06:00
MHDA- 2014/09/23 06:00
CRDT- 2013/09/10 06:00
PHST- 2013/02/13 00:00 [received]
PHST- 2013/06/05 00:00 [revised]
PHST- 2013/07/01 00:00 [accepted]
PHST- 2013/09/10 06:00 [entrez]
PHST- 2013/09/10 06:00 [pubmed]
PHST- 2014/09/23 06:00 [medline]
AID - 10.1002/mds.25626 [doi]
PST - ppublish
SO  - Mov Disord. 2014 Jan;29(1):90-6. doi: 10.1002/mds.25626. Epub 2013 Sep 6.