PMID- 24015628
OWN - NLM
STAT- MEDLINE
DCOM- 20140123
LR  - 20130910
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 27
IP  - 12
DP  - 2013 Jun
TI  - [Expression and clinical significance of TLR2 in laryngeal carcinoma tissue].
PG  - 629-32
AB  - OBJECTIVE: To investigate the expression levels of Toll-like receptor 2 (TLR2) in 
      laryngeal squamous cell carcinoma (LSCC) tissue and the adjacent normal 
      epithelial tissue. METHOD: Reverse transcriptase-polymerase chain 
      reaction(RT-PCR) and Western-blot were used to detect the expression of TLR2 mRNA 
      and protein levels in the tumors and adjacent normal epithelial tissues in 22 
      patients with LSCC, while vocal cord polyps were used as control. RESULT: RT-PCR 
      demonstrated that TLR2 mRNA expressed obviously in both of tumor and adjacent 
      tissue, but rarely in control. The expression levels of TLR2 mRNA in tumor is 
      higher than that in adjacent normal epithelial tissue (t=4.279, P<0.01). It's 
      expression intensity was closely related to LSCC clinical stage (F=5.496, 
      P<0.05)and lymph node metastasis status (N stage of tumor) (F = 4.271, P<0.05). 
      The protein levels of TLR2 were consistent with mRNA expression. CONCLUSION: Both 
      mRNA and protein levels of TLR2 were obviously elevated in LSCC, which were 
      associated closely with tumor clinical stage and lymph node metastasis. It is 
      indicated that TLR2 may play an important role by multiple mechanism in laryngeal 
      carcinoma process.
FAU - Wang, Xiaojing
AU  - Wang X
AD  - Institute of Basic Medicine, Shandong Academy of Medical Sciences and Ji'nan 
      University School of Medical and Life Science, Ji'nan, 250062, China.
FAU - Wang, Junfu
AU  - Wang J
FAU - Liu, Lin
AU  - Liu L
FAU - Liang, Guiling
AU  - Liang G
FAU - Chen, Xuemei
AU  - Chen X
FAU - Xu, Xiaoqun
AU  - Xu X
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (TLR2 protein, human)
RN  - 0 (Toll-Like Receptor 2)
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/*pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Toll-Like Receptor 2/*metabolism
EDAT- 2013/09/11 06:00
MHDA- 2014/01/24 06:00
CRDT- 2013/09/11 06:00
PHST- 2013/09/11 06:00 [entrez]
PHST- 2013/09/11 06:00 [pubmed]
PHST- 2014/01/24 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Jun;27(12):629-32.