PMID- 24016221
OWN - NLM
STAT- MEDLINE
DCOM- 20140722
LR  - 20220408
IS  - 1471-2369 (Electronic)
IS  - 1471-2369 (Linking)
VI  - 14
DP  - 2013 Sep 9
TI  - Relationship between estimated glomerular filtration rate, albuminuria, and 
      oxidant status in the Japanese population.
PG  - 191
LID - 10.1186/1471-2369-14-191 [doi]
AB  - BACKGROUND: In the general population, reported levels of oxidative stress and 
      antioxidant potential seem to vary. The aim of this study was to investigate the 
      levels of oxidant status markers in relation to estimated glomerular filtration 
      rate (eGFR) and albuminuria in Japanese population. METHODS: Data were analyzed 
      from 8335 individuals who underwent a general health screening test. For the 
      estimation of albuminuria, urinary albumin-to-creatinine ratio (UAER) was 
      calculated. Oxidant status was determined by assessing derivatives of reactive 
      oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP). RESULTS: 
      After adjusting for age, high blood pressure, depressor agent use, CRP, smoking 
      status, multivariate logistic regression analysis showed that the lowest eGFR 
      quartile was associated negatively with the top d-ROM quartile in men (odds ratio 
      0.78 [95% CI 0.62-0.98, P = 0.034]) and the highest UAER was associated with the 
      top d-ROM in men (odds ratio 1.68) [95% CI 1.35-2.10, P < 0.001]. In addition, 
      both the first eGFR quartile and the fourth UAER quartile showed significant 
      positive association with low BAP levels in men, but not in women. CONCLUSIONS: 
      Among men who underwent general health screening, lower eGFR and increased 
      albuminuria was negatively and positively, respectively, associated with higher 
      oxidative stress levels, whereas both conditions were positively associated with 
      lower antioxidant potential levels.
FAU - Ishizaka, Yuko
AU  - Ishizaka Y
AD  - Department of Cardiology, Osaka Medical College, 2-7 Daigakumachi, Takatsuki-shi, 
      569-8686 Osaka, Japan. ishizaka@poh.osaka-med.ac.jp.
FAU - Yamakado, Minoru
AU  - Yamakado M
FAU - Toda, Akiko
AU  - Toda A
FAU - Tani, Mizuki
AU  - Tani M
FAU - Ishizaka, Nobukazu
AU  - Ishizaka N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130909
PL  - England
TA  - BMC Nephrol
JT  - BMC nephrology
JID - 100967793
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Albuminuria/*epidemiology/*physiopathology
MH  - Causality
MH  - Comorbidity
MH  - Female
MH  - *Glomerular Filtration Rate
MH  - Humans
MH  - Japan/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Reactive Oxygen Species/*blood
MH  - Renal Insufficiency, Chronic/*epidemiology/*physiopathology
MH  - Reproducibility of Results
MH  - Risk Factors
MH  - Sensitivity and Specificity
MH  - Statistics as Topic
PMC - PMC3844606
EDAT- 2013/09/11 06:00
MHDA- 2014/07/23 06:00
PMCR- 2013/09/09
CRDT- 2013/09/11 06:00
PHST- 2013/04/05 00:00 [received]
PHST- 2013/09/04 00:00 [accepted]
PHST- 2013/09/11 06:00 [entrez]
PHST- 2013/09/11 06:00 [pubmed]
PHST- 2014/07/23 06:00 [medline]
PHST- 2013/09/09 00:00 [pmc-release]
AID - 1471-2369-14-191 [pii]
AID - 10.1186/1471-2369-14-191 [doi]
PST - epublish
SO  - BMC Nephrol. 2013 Sep 9;14:191. doi: 10.1186/1471-2369-14-191.