PMID- 24016689
OWN - NLM
STAT- MEDLINE
DCOM- 20140626
LR  - 20210503
IS  - 1872-6844 (Electronic)
IS  - 0920-1211 (Linking)
VI  - 107
IP  - 1-2
DP  - 2013 Nov
TI  - Treatment and course of different subtypes of status epilepticus.
PG  - 156-62
LID - S0920-1211(13)00195-2 [pii]
LID - 10.1016/j.eplepsyres.2013.08.001 [doi]
AB  - Since randomized controlled trials are difficult to perform for ethical reasons 
      in a potentially deadly condition like status epilepticus (SE), a retrospective 
      database analysis may be welcome to broaden the evidence for the treatment of SE. 
      In this retrospective study we evaluated every SE treatment at the neurological 
      department of the University of Rostock from January 2000 to December 2009 in 
      order to determine the efficacy of different antiepileptic drugs (AEDs) in 
      terminating different kinds of SE. We analyzed the frequency of refractory 
      courses in different types of SE, at which time which AED was administered and at 
      which time which AED was effective to terminate the different epileptic 
      conditions. A second aim of this study was to evaluate the course and the outcome 
      of different kinds of SE. Statistical comparisons were performed with the 
      chi(2)-test. 167 episodes of SE in 118 patients could be evaluated. The efficacy 
      rates of AEDs differed significantly, mainly due to the superior efficacy of 
      clonazepam (CZP). CZP seemed to be more effective than DZP, LEV, MDM and VPA in 
      terminating generalized convulsive status epilepticus (GCSE), whereas there was 
      no significant difference in the efficacy for terminating nonconvulsive status 
      epilepticus (NCSE) and epilepsia partialis continua (EPC) between the used AEDs. 
      Anaesthesia and CZP both terminated GCSE more effectively than NCSE and EPC. 
      Concerning the course of the different kinds of SE the following results were 
      obtained: 13 patients died during hospital treatment. Treatment in NCSE and EPC 
      started significantly later than in GCSE. There was no significant difference in 
      mortality between the types of SE. However the frequency of refractory courses 
      differed between the types of SE. At the time of SE termination without the 
      administration of anaesthesia a combination therapy using 2 or more AEDs was 
      established in most episodes.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Rantsch, Kristin
AU  - Rantsch K
AD  - Klinik und Poliklinik fur Neurologie, Universitatsmedizin Rostock, Gehlsheimer 
      Str. 20, 18147 Rostock, Germany. Electronic address: 
      kristin.rantsch@uni-rostock.de.
FAU - Walter, Uwe
AU  - Walter U
FAU - Wittstock, Matthias
AU  - Wittstock M
FAU - Benecke, Reiner
AU  - Benecke R
FAU - Rosche, Johannes
AU  - Rosche J
LA  - eng
PT  - Journal Article
DEP - 20130823
PL  - Netherlands
TA  - Epilepsy Res
JT  - Epilepsy research
JID - 8703089
RN  - 0 (Anticonvulsants)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anticonvulsants/*therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Status Epilepticus/*drug therapy/mortality/physiopathology
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Clonazepam
OT  - Combination therapy
OT  - Outcome criteria
OT  - Refractory status epilepticus
OT  - Treatment delay
EDAT- 2013/09/11 06:00
MHDA- 2014/06/27 06:00
CRDT- 2013/09/11 06:00
PHST- 2013/03/19 00:00 [received]
PHST- 2013/06/25 00:00 [revised]
PHST- 2013/08/03 00:00 [accepted]
PHST- 2013/09/11 06:00 [entrez]
PHST- 2013/09/11 06:00 [pubmed]
PHST- 2014/06/27 06:00 [medline]
AID - S0920-1211(13)00195-2 [pii]
AID - 10.1016/j.eplepsyres.2013.08.001 [doi]
PST - ppublish
SO  - Epilepsy Res. 2013 Nov;107(1-2):156-62. doi: 10.1016/j.eplepsyres.2013.08.001. 
      Epub 2013 Aug 23.