PMID- 24018547
OWN - NLM
STAT- MEDLINE
DCOM- 20140915
LR  - 20131107
IS  - 1533-712X (Electronic)
IS  - 0271-0749 (Linking)
VI  - 33
IP  - 6
DP  - 2013 Dec
TI  - Brain-derived neurotrophic factor serum concentrations in acute depressive 
      patients increase during lithium augmentation of antidepressants.
PG  - 806-9
LID - 10.1097/JCP.0b013e3182a412b8 [doi]
AB  - In recent years, lithium has proved an effective augmentation strategy of 
      antidepressants in both acute and treatment-resistant depression. Neuroprotective 
      and procognitive effects of lithium have been evidenced. Brain-derived 
      neurotrophic factor (BDNF) has been shown to play a key role in the 
      pathophysiology of several neurological and psychiatric disorders. The BDNF 
      hypothesis of depression postulates that a loss of BDNF is directly involved in 
      the pathophysiology of depression, and its restoration may underlie the 
      therapeutic efficacy of antidepressant treatments. Brain-derived neurotrophic 
      factor serum concentrations were measured in a total of 83 acutely depressed 
      patients before and after 4 weeks of lithium augmentation. A significant BDNF 
      increase has been found during treatment (F2,81 = 5.04, P < 0.05). Brain-derived 
      neurotrophic factor concentrations at baseline correlated negatively with 
      relative Hamilton Depression Scale change after treatment with lithium (n = 83; r 
      = -0.23; P < 0.05). This is the first study showing that lithium augmentation of 
      an antidepressant strategy can increase BDNF serum concentrations. Our study 
      replicates previous findings showing that serum BDNF levels in patients with 
      depressive episodes increase during effective antidepressant treatment. Further 
      studies are needed to separate specific effects of different antidepressants on 
      BDNF concentration and address potential BDNF downstream mechanisms.
FAU - Ricken, Roland
AU  - Ricken R
AD  - From the *Department of Psychiatry and Psychotherapy, Charite University Medicine 
      Berlin, Campus Mitte; daggerDepartment of Psychiatry and Psychotherapy, 
      Schlossparkklinik; double daggerDepartment of Psychiatry and Psychotherapy, Vivantes 
      Wenckebach Klinikum, Berlin, Germany; and  section signDepartment of Psychiatry and 
      Psychotherapy, University of Basel, Basel, Switzerland.
FAU - Adli, Mazda
AU  - Adli M
FAU - Lange, Claudia
AU  - Lange C
FAU - Krusche, Esther
AU  - Krusche E
FAU - Stamm, Thomas J
AU  - Stamm TJ
FAU - Gaus, Sebastian
AU  - Gaus S
FAU - Koehler, Stephan
AU  - Koehler S
FAU - Nase, Sarah
AU  - Nase S
FAU - Bschor, Tom
AU  - Bschor T
FAU - Richter, Christoph
AU  - Richter C
FAU - Steinacher, Bruno
AU  - Steinacher B
FAU - Heinz, Andreas
AU  - Heinz A
FAU - Rapp, Michael A
AU  - Rapp MA
FAU - Borgwardt, Stefan
AU  - Borgwardt S
FAU - Hellweg, Rainer
AU  - Hellweg R
FAU - Lang, Undine E
AU  - Lang UE
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Psychopharmacol
JT  - Journal of clinical psychopharmacology
JID - 8109496
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 2BMD2GNA4V (Lithium Carbonate)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Antidepressive Agents/administration & dosage/pharmacology/*therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Depressive Disorder, Major/blood/*drug therapy/physiopathology
MH  - Depressive Disorder, Treatment-Resistant/blood/drug therapy/physiopathology
MH  - Drug Therapy, Combination
MH  - Female
MH  - Humans
MH  - Lithium Carbonate/administration & dosage/pharmacology/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Treatment Outcome
EDAT- 2013/09/11 06:00
MHDA- 2014/09/16 06:00
CRDT- 2013/09/11 06:00
PHST- 2013/09/11 06:00 [entrez]
PHST- 2013/09/11 06:00 [pubmed]
PHST- 2014/09/16 06:00 [medline]
AID - 10.1097/JCP.0b013e3182a412b8 [doi]
PST - ppublish
SO  - J Clin Psychopharmacol. 2013 Dec;33(6):806-9. doi: 10.1097/JCP.0b013e3182a412b8.