PMID- 24019395
OWN - NLM
STAT- MEDLINE
DCOM- 20140822
LR  - 20131105
IS  - 1538-7755 (Electronic)
IS  - 1055-9965 (Linking)
VI  - 22
IP  - 11
DP  - 2013 Nov
TI  - Lack of evidence for human T-lymphotropic virus type 1 and mouse mammary 
      tumor-like virus involvement in the genesis of childhood acute lymphoblastic 
      leukemia.
PG  - 2130-3
LID - 10.1158/1055-9965.EPI-13-0539 [doi]
AB  - BACKGROUND: In Mexico City, the incidence of childhood acute lymphoblastic 
      leukemia (ALL) is one of the highest in the world; epidemiologic evidence 
      suggests that infectious agents could be involved in the genesis of this disease. 
      Early transmitted oncogenic retroviruses infecting lymphocytes are important 
      candidates. METHODS: PCR-based assays were used to screen viral genomic sequences 
      of human T-cell lymphotrophic virus, type 1 (HTLV1) and mouse mammary tumor virus 
      (MMTV)-like virus (MMTV-LV) in leukemic cells from 67 pediatric patients with 
      ALL. RESULTS: Viral genomic sequences were not detected in any sample by neither 
      standard nor nested PCR. CONCLUSIONS: Because of the methodologic strictness and 
      high statistical power of the study, these results suggest that HTLV1 and MMTV-LV 
      are not involved in the genesis of childhood ALL in Mexican children. IMPACT: To 
      our knowledge, this is the first work exploring the direct participation of HTLV1 
      and MMTV-LV retroviruses in childhood ALL development.
CI  - (c)2013 AACR.
FAU - Morales-Sanchez, Abigail
AU  - Morales-Sanchez A
AD  - Authors' Affiliations: Units of Medical Research in Clinical Epidemiology and 
      Infectious and Parasitic Diseases, Pediatric Hospital, National Medical Center 
      XXI Century, Mexican Institute of Social Security; Medicine Faculty, National 
      Autonomous University of Mexico; and Mexican Inter-institutional Group for the 
      Identification of the Causes of Childhood Leukaemia (MIGICCL), Mexico City, 
      Mexico.
FAU - Bernaldez-Rios, Roberto
AU  - Bernaldez-Rios R
FAU - Alvarez-Rodriguez, Francisco Javier
AU  - Alvarez-Rodriguez FJ
FAU - Bekker-Mendez, Vilma Carolina
AU  - Bekker-Mendez VC
FAU - Fajardo-Gutierrez, Arturo
AU  - Fajardo-Gutierrez A
FAU - de Diego Flores-Chapa, Jose
AU  - de Diego Flores-Chapa J
FAU - Flores-Lujano, Janet
AU  - Flores-Lujano J
FAU - Jimenez-Hernandez, Elva
AU  - Jimenez-Hernandez E
FAU - Penaloza-Gonzalez, Jose Gabriel
AU  - Penaloza-Gonzalez JG
FAU - Del Carmen Rodriguez-Zepeda, Maria
AU  - Del Carmen Rodriguez-Zepeda M
FAU - Torres-Nava, Jose Refugio
AU  - Torres-Nava JR
FAU - Velazquez-Avina, Martha Margarita
AU  - Velazquez-Avina MM
FAU - Amador-Sanchez, Raquel
AU  - Amador-Sanchez R
FAU - Alvarado-Ibarra, Martha
AU  - Alvarado-Ibarra M
FAU - Reyes-Zepeda, Nancy
AU  - Reyes-Zepeda N
FAU - Espinosa-Elizondo, Rosa Martha
AU  - Espinosa-Elizondo RM
FAU - Fuentes-Panana, Ezequiel M
AU  - Fuentes-Panana EM
FAU - Mejia-Arangure, Juan Manuel
AU  - Mejia-Arangure JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130909
PL  - United States
TA  - Cancer Epidemiol Biomarkers Prev
JT  - Cancer epidemiology, biomarkers & prevention : a publication of the American 
      Association for Cancer Research, cosponsored by the American Society of 
      Preventive Oncology
JID - 9200608
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Human T-lymphotropic virus 1/genetics/*isolation & purification
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Male
MH  - Mammary Tumor Virus, Mouse/genetics/*isolation & purification
MH  - Polymerase Chain Reaction
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*virology
EDAT- 2013/09/11 06:00
MHDA- 2014/08/26 06:00
CRDT- 2013/09/11 06:00
PHST- 2013/09/11 06:00 [entrez]
PHST- 2013/09/11 06:00 [pubmed]
PHST- 2014/08/26 06:00 [medline]
AID - 1055-9965.EPI-13-0539 [pii]
AID - 10.1158/1055-9965.EPI-13-0539 [doi]
PST - ppublish
SO  - Cancer Epidemiol Biomarkers Prev. 2013 Nov;22(11):2130-3. doi: 
      10.1158/1055-9965.EPI-13-0539. Epub 2013 Sep 9.