PMID- 24019552
OWN - NLM
STAT- MEDLINE
DCOM- 20131119
LR  - 20211021
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Print)
IS  - 0022-1007 (Linking)
VI  - 210
IP  - 10
DP  - 2013 Sep 23
TI  - Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not 
      affect commensalism.
PG  - 2011-24
LID - 10.1084/jem.20130728 [doi]
AB  - Dendritic cells (DCs) in the intestinal lamina propria (LP) are composed of two 
      CD103(+) subsets that differ in CD11b expression. We report here that Langerin is 
      expressed by human LP DCs and that transgenic human langerin drives expression in 
      CD103(+)CD11b(+) LP DCs in mice. This subset was ablated in huLangerin-DTA mice, 
      resulting in reduced LP Th17 cells without affecting Th1 or T reg cells. Notably, 
      cognate DC-T cell interactions were not required for Th17 development, as this 
      response was intact in huLangerin-Cre I-Abeta(fl/fl) mice. In contrast, responses to 
      intestinal infection or flagellin administration were unaffected by the absence 
      of CD103(+)CD11b(+) DCs. huLangerin-DTA x BatF3(-/-) mice lacked both CD103(+) LP 
      DC subsets, resulting in defective gut homing and fewer LP T reg cells. Despite 
      these defects in LP DCs and resident T cells, we did not observe alterations of 
      intestinal microbial communities. Thus, CD103(+) LP DC subsets control T cell 
      homeostasis through both nonredundant and overlapping mechanisms.
FAU - Welty, Nathan E
AU  - Welty NE
AD  - Department of Dermatology, Center for Immunology and 2 Department of Soil, Water, 
      and Climate, Biotechnology Institute, University of Minnesota, Minneapolis, MN 
      55455.
FAU - Staley, Christopher
AU  - Staley C
FAU - Ghilardi, Nico
AU  - Ghilardi N
FAU - Sadowsky, Michael J
AU  - Sadowsky MJ
FAU - Igyarto, Botond Z
AU  - Igyarto BZ
FAU - Kaplan, Daniel H
AU  - Kaplan DH
LA  - eng
GR  - AR060744/AR/NIAMS NIH HHS/United States
GR  - R01 AR060744/AR/NIAMS NIH HHS/United States
GR  - DK097856/DK/NIDDK NIH HHS/United States
GR  - F30 DK097856/DK/NIDDK NIH HHS/United States
GR  - R01 AR056632/AR/NIAMS NIH HHS/United States
GR  - T32 GM008244/GM/NIGMS NIH HHS/United States
GR  - AR056632/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130909
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Antigens, CD)
RN  - 0 (CD11b Antigen)
RN  - 0 (CD207 protein, human)
RN  - 0 (Diphtheria Toxin)
RN  - 0 (Integrin alpha Chains)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Mannose-Binding Lectins)
RN  - 0 (alpha E integrins)
SB  - IM
MH  - Animals
MH  - Antigens, CD/genetics/metabolism
MH  - CD11b Antigen/metabolism
MH  - Dendritic Cells/*immunology/metabolism
MH  - Diphtheria Toxin/genetics
MH  - Homeostasis/genetics/*immunology
MH  - Humans
MH  - Immunophenotyping
MH  - Integrin alpha Chains/metabolism
MH  - Intestinal Mucosa/*immunology/*microbiology
MH  - Lectins, C-Type/genetics
MH  - Mannose-Binding Lectins/genetics
MH  - Metagenome
MH  - Mice
MH  - Mice, Transgenic
MH  - Phenotype
MH  - T-Lymphocyte Subsets/*immunology/metabolism
MH  - T-Lymphocytes, Regulatory/immunology/metabolism
MH  - Th17 Cells/immunology/metabolism
PMC - PMC3782055
EDAT- 2013/09/11 06:00
MHDA- 2013/11/20 06:00
PMCR- 2014/03/23
CRDT- 2013/09/11 06:00
PHST- 2013/09/11 06:00 [entrez]
PHST- 2013/09/11 06:00 [pubmed]
PHST- 2013/11/20 06:00 [medline]
PHST- 2014/03/23 00:00 [pmc-release]
AID - jem.20130728 [pii]
AID - 20130728 [pii]
AID - 10.1084/jem.20130728 [doi]
PST - ppublish
SO  - J Exp Med. 2013 Sep 23;210(10):2011-24. doi: 10.1084/jem.20130728. Epub 2013 Sep 
      9.