PMID- 24019626
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130910
LR  - 20211021
IS  - 0971-6866 (Print)
IS  - 1998-362X (Electronic)
IS  - 1998-362X (Linking)
VI  - 19
IP  - 2
DP  - 2013 Apr
TI  - Human leukocyte antigen alleles, genotypes and haplotypes frequencies in renal 
      transplant donors and recipients from West Central India.
PG  - 219-32
LID - 10.4103/0971-6866.116122 [doi]
AB  - BACKGROUND: Human leukocyte antigen (HLA) is comprised of a highly polymorphic 
      set of genes which determines the histocompatibility of organ transplantation. 
      The present study was undertaken to identify HLA class I and class II allele, 
      genotype and haplotype frequencies in renal transplant recipients and donors from 
      West Central India. MATERIALS AND METHODS: HLA typing was carried out using 
      Polymerase Chain Reaction-Sequence Specific Primer in 552 live related and 
      unrelated renal transplant recipients and donors. RESULTS: The most frequent HLA 
      class I and class II alleles and their frequencies in recipients were 
      HLA-AFNx0101 (0.1685) and AFNx0102 (0.1649), HLA-BFNx0135 (0.1322), and HLA-DR 
      beta 1 (DRB 1)FNx0115 (0.2192), whereas in donors, these were HLA-AFNx0102 
      (0.1848) and AFNx0101 (0.1667), HLA-BFNx0135 (0.1359), and HLA-DRB1FNx0115 
      (0.2409). The two-locus haplotype statistical analysis revealed HLA-AFNx0102-B61 
      as the most common haplotype with the frequency of 0.0487 and 0.0510 in 
      recipients and donors, respectively. Further, among the three locus haplotypes 
      HLA-AFNx0133-BFNx0144-DRB1FNx0107 and HLA-AFNx0102-BFNx0161-DRB1FNx0115 were the 
      most common haplotypes with frequencies 0.0362 and 0.0326, respectively in 
      recipients and 0.0236 and 0.0323, respectively in donors. Genotype frequency 
      revealed a high prevalence of genotype HLA-AFNx0102/AFNx0124 in recipients 
      (0.058) compared to donors (0.0109) whereas low prevalence of 
      HLA-AFNx0101/AFNx0102 in recipients (0.0435) than in donors (0.0797). The 
      phylogenetic and principal component analysis of HLA allele and haplotype 
      frequency distribution revealed genetic similarities of various ethnic groups. 
      Further, case control analysis provides preliminary evidence of association of 
      HLA-A genotype (P < 0.05) with renal failure. CONCLUSION: This study will be 
      helpful in suitable donor search besides providing valuable information for 
      population genetics and HLA disease association analysis.
FAU - Patel, Jaina S
AU  - Patel JS
AD  - Department of Animal Biotechnology, College of Veterinary Science and Animal 
      Husbandry, Anand Agricultural University, Anand, Gujarat, India.
FAU - Patel, Manisha M
AU  - Patel MM
FAU - Koringa, Prakash G
AU  - Koringa PG
FAU - Shah, Tejas M
AU  - Shah TM
FAU - Patel, Amrutlal K
AU  - Patel AK
FAU - Tripathi, Ajai K
AU  - Tripathi AK
FAU - Mathew, Anila
AU  - Mathew A
FAU - Rajapurkar, Mohan M
AU  - Rajapurkar MM
FAU - Joshi, Chaitanya G
AU  - Joshi CG
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Hum Genet
JT  - Indian journal of human genetics
JID - 101223637
PMC - PMC3758731
OTO - NOTNLM
OT  - Allele
OT  - genotype
OT  - haplotype
OT  - human leukocyte antigens frequencies
OT  - polymorphism
OT  - renal transplant
COIS- Conflict of Interest: None declared.
EDAT- 2013/09/11 06:00
MHDA- 2013/09/11 06:01
PMCR- 2013/04/01
CRDT- 2013/09/11 06:00
PHST- 2013/09/11 06:00 [entrez]
PHST- 2013/09/11 06:00 [pubmed]
PHST- 2013/09/11 06:01 [medline]
PHST- 2013/04/01 00:00 [pmc-release]
AID - IJHG-19-219 [pii]
AID - 10.4103/0971-6866.116122 [doi]
PST - ppublish
SO  - Indian J Hum Genet. 2013 Apr;19(2):219-32. doi: 10.4103/0971-6866.116122.