PMID- 24020822
OWN - NLM
STAT- MEDLINE
DCOM- 20140623
LR  - 20220321
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Print)
IS  - 0021-8561 (Linking)
VI  - 61
IP  - 38
DP  - 2013 Sep 25
TI  - Nanoencapsulation enhances epigallocatechin-3-gallate stability and its 
      antiatherogenic bioactivities in macrophages.
PG  - 9200-9
LID - 10.1021/jf4023004 [doi]
AB  - We have successfully synthesized (-)-epigallocatechin-3-gallate (EGCG) 
      encapsulated nanostructured lipid carriers (NLCE) and chitosan-coated NLCE 
      (CSNLCE) using natural lipids, surfactant, chitosan, and EGCG. Nanoencapsulation 
      dramatically improved EGCG stability. CSNLCE significantly increased EGCG content 
      in THP-1-derived macrophages compared with nonencapsulated EGCG. As compared to 
      10 muM nonencapsulated EGCG, both NLCE and CSNLCE at the same concentration 
      significantly decreased macrophage cholesteryl ester content. NLCE and CSNLCE 
      significantly decreased mRNA levels and protein secretion of monocyte 
      chemoattractant protein-1 (MCP-1) levels in macrophages, respectively. These data 
      suggest that nanoencapsulated EGCG may have a potential to inhibit 
      atherosclerotic lesion development through decreasing macrophage cholesterol 
      content and MCP-1 expression.
FAU - Zhang, Jia
AU  - Zhang J
AD  - Nutritional Science Program, Texas Tech University, Lubbock, TX, 79409.
FAU - Nie, Shufang
AU  - Nie S
AD  - Nutritional Science Program, Texas Tech University, Lubbock, TX, 79409.
FAU - Wang, Shu
AU  - Wang S
AD  - Nutritional Science Program, Texas Tech University, Lubbock, TX, 79409.
LA  - eng
GR  - R15 AT007013/AT/NCCIH NIH HHS/United States
GR  - R15AT007013/AT/NCCIH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130910
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (CCL2 protein, human)
RN  - 0 (Cardiovascular Agents)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Plant Extracts)
RN  - 8R1V1STN48 (Catechin)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - BQM438CTEL (epigallocatechin gallate)
SB  - IM
MH  - Atherosclerosis/*drug therapy/genetics/metabolism
MH  - Camellia sinensis/*chemistry
MH  - Cardiovascular Agents/*chemistry/pharmacology
MH  - Catechin/*analogs & derivatives/chemistry/pharmacology
MH  - Cell Line
MH  - Chemokine CCL2/genetics/metabolism
MH  - Cholesterol/metabolism
MH  - Drug Compounding
MH  - Drug Stability
MH  - Humans
MH  - Macrophages/*drug effects/metabolism
MH  - Nanoparticles/chemistry
MH  - Plant Extracts/*chemistry/pharmacology
PMC - PMC3840090
MID - NIHMS523585
EDAT- 2013/09/12 06:00
MHDA- 2014/06/24 06:00
PMCR- 2014/09/25
CRDT- 2013/09/12 06:00
PHST- 2013/09/12 06:00 [entrez]
PHST- 2013/09/12 06:00 [pubmed]
PHST- 2014/06/24 06:00 [medline]
PHST- 2014/09/25 00:00 [pmc-release]
AID - 10.1021/jf4023004 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2013 Sep 25;61(38):9200-9. doi: 10.1021/jf4023004. Epub 2013 
      Sep 10.