PMID- 24021607
OWN - NLM
STAT- MEDLINE
DCOM- 20140609
LR  - 20211021
IS  - 1421-9859 (Electronic)
IS  - 0378-5866 (Print)
IS  - 0378-5866 (Linking)
VI  - 35
IP  - 5
DP  - 2013
TI  - Enhanced brain-derived neurotrophic factor signaling in the nucleus accumbens of 
      juvenile rats.
PG  - 384-95
LID - 10.1159/000351026 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) signaling through its receptor, 
      tropomyosin receptor kinase B (TrkB), plays a critical role in neural plasticity 
      and its dysregulation in striatum and prefrontal cortex (PFC) has been implicated 
      in the etiology of mental health disorders such schizophrenia and drug addiction. 
      In the present study, we characterized age-dependent differences in BDNF 
      signaling and TrkB expression within the nucleus accumbens (NAc), caudate putamen 
      (CP) and PFC in rats and determined the effects of administration of the dopamine 
      agonist, SKF 83959, which activates the Gq-coupled dopamine receptors, the 
      dopamine D5 receptor and the D1-D2 receptor heteromer. As proBDNF binds with high 
      affinity to the p75 neurotrophin receptor (p75NTR), expression levels of these 
      proteins were also assessed. The present findings showed that juvenile rats (aged 
      26-28 days) exhibited significantly elevated basal BDNF expression and activation 
      of full-length TrkB (TrkBfull) in NAc compared to their adult counterparts, as 
      evidenced by increased TrkBfull phosphorylation. These changes were concomitant 
      with an increase in the relative expression of TrkBfull compared to the truncated 
      isoform, TrkB.T1, in NAc and CP. Conversely, in PFC the basal expression of BDNF 
      in juvenile rats was significantly lower than in adult rats with an elevated 
      relative expression of TrkBfull. Acute administration of SKF 83959 to juvenile 
      rats abolished the age-dependent differences in BDNF expression in NAc and PFC, 
      and in the relative expression of TrkBfull in NAc and CP. Together these findings 
      indicate that the expression and/or signaling of BDNF and TrkB in striatum and 
      PFC of juvenile rats is fundamentally different from that of adult rats, a 
      finding that may have implications in neuropsychiatric disorders that exhibit 
      age-dependent susceptibility such as schizophrenia and drug addiction.
CI  - Copyright (c) 2013 S. Karger AG, Basel.
FAU - Perreault, Melissa L
AU  - Perreault ML
AD  - Centre for Addiction and Mental Health, Departments of Pharmacology, University 
      of Toronto, Toronto, Ont., Canada.
FAU - Fan, Theresa
AU  - Fan T
FAU - O'Dowd, Brian F
AU  - O'Dowd BF
FAU - George, Susan R
AU  - George SR
LA  - eng
GR  - R01 DA007223/DA/NIDA NIH HHS/United States
GR  - CAPMC/CIHR/Canada
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130907
PL  - Switzerland
TA  - Dev Neurosci
JT  - Developmental neuroscience
JID - 7809375
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dopamine Agonists)
RN  - 0 (Receptor, Nerve Growth Factor)
RN  - 67287-49-4 (2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine)
RN  - 80751-85-5 (SK&F 83959)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine/analogs & 
      derivatives/pharmacology
MH  - Age Factors
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Caudate Nucleus/drug effects/metabolism
MH  - Dopamine Agonists/pharmacology
MH  - Male
MH  - Neurons/drug effects/*metabolism
MH  - Nucleus Accumbens/drug effects/*metabolism
MH  - Phosphorylation/drug effects
MH  - Prefrontal Cortex/drug effects/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, Nerve Growth Factor/metabolism
MH  - Receptor, trkB/*metabolism
MH  - Signal Transduction/drug effects/*physiology
PMC - PMC4243163
MID - NIHMS512966
EDAT- 2013/09/12 06:00
MHDA- 2014/06/10 06:00
PMCR- 2014/11/25
CRDT- 2013/09/12 06:00
PHST- 2012/10/17 00:00 [received]
PHST- 2013/03/28 00:00 [accepted]
PHST- 2013/09/12 06:00 [entrez]
PHST- 2013/09/12 06:00 [pubmed]
PHST- 2014/06/10 06:00 [medline]
PHST- 2014/11/25 00:00 [pmc-release]
AID - 000351026 [pii]
AID - 10.1159/000351026 [doi]
PST - ppublish
SO  - Dev Neurosci. 2013;35(5):384-95. doi: 10.1159/000351026. Epub 2013 Sep 7.