PMID- 24022917
OWN - NLM
STAT- MEDLINE
DCOM- 20140604
LR  - 20191210
IS  - 1520-6300 (Electronic)
IS  - 1042-0533 (Linking)
VI  - 25
IP  - 6
DP  - 2013 Nov-Dec
TI  - Adipose tissue: another target organ for lead accumulation? A study on Sardinian 
      children (Italy).
PG  - 789-94
LID - 10.1002/ajhb.22448 [doi]
AB  - OBJECTIVES: This study analyzes the relationship between lead levels and adipose 
      tissue in Sardinian children. As an environmental pollutant, lead occurs in two 
      different chemical forms: inorganic and organic lead; organic lead is present in 
      the environment mainly as lead-alkyls (tetramethyl and tetraethyl lead). The 
      lead-alkyls are characterized by their liposolubility; because of this 
      characteristic, the behavior of organic Pb in the organism is similar to that of 
      persistent organic pollutants (POPs). In fact, the high liposolubility of POPs, 
      synthetic chemical substances highly resistant to biodegradation in both the 
      environment and the human body, gives them a preferential tendency to accumulate 
      in adipose tissue. METHODS: The study sample consisted of 759 children between 11 
      and 15 years resident in various municipalities of Sardinia. Hair lead levels 
      (PbH) were used as the biomarker of exposure, while several anthropometric 
      indexes were adopted to evaluate the adipose tissue: weight, body mass index, 
      waist circumference, waist to hip circumference ratio, and sum of skinfolds 
      (Sigmaskf). RESULTS: The results of the multivariate ridge regression analysis, 
      controlling for sex and age, show a significant positive relationship between 
      logPbH and logSigmaskf but not the other adiposity indicators. CONCLUSIONS: This 
      results suggests that organic lead tends to accumulate in adipose tissue, 
      although it would be appropriate to measure lead levels in the adipose tissue 
      itself in order to verify the results. Hence this tissue could be considered a 
      possible new biological matrix for the evaluation of environmental lead exposure.
CI  - Copyright (c) 2013 Wiley Periodicals, Inc.
FAU - Vallascas, Elisabetta
AU  - Vallascas E
AD  - Department of Environmental and Life Sciences, Anthropological Sciences Research 
      Unit, Cittadella Universitaria, 09042 Monserrato, University of Cagliari, 
      Sardinia, Italy.
FAU - De Micco, Alessandro
AU  - De Micco A
FAU - Deiana, Fabrizio
AU  - Deiana F
FAU - Banni, Sebastiano
AU  - Banni S
FAU - Sanna, Emanuele
AU  - Sanna E
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130910
PL  - United States
TA  - Am J Hum Biol
JT  - American journal of human biology : the official journal of the Human Biology 
      Council
JID - 8915029
RN  - 0 (Biomarkers)
RN  - 0 (Environmental Pollutants)
RN  - 2P299V784P (Lead)
SB  - IM
MH  - *Adiposity
MH  - Adolescent
MH  - Anthropometry
MH  - Biomarkers/metabolism
MH  - Child
MH  - Cross-Sectional Studies
MH  - *Environmental Exposure
MH  - Environmental Monitoring/*methods
MH  - Environmental Pollutants/*metabolism
MH  - Female
MH  - Hair/*metabolism
MH  - Humans
MH  - Italy
MH  - Lead/*metabolism
MH  - Male
MH  - Risk Factors
EDAT- 2013/09/12 06:00
MHDA- 2014/06/05 06:00
CRDT- 2013/09/12 06:00
PHST- 2012/12/12 00:00 [received]
PHST- 2013/08/08 00:00 [revised]
PHST- 2013/08/08 00:00 [accepted]
PHST- 2013/09/12 06:00 [entrez]
PHST- 2013/09/12 06:00 [pubmed]
PHST- 2014/06/05 06:00 [medline]
AID - 10.1002/ajhb.22448 [doi]
PST - ppublish
SO  - Am J Hum Biol. 2013 Nov-Dec;25(6):789-94. doi: 10.1002/ajhb.22448. Epub 2013 Sep 
      10.