PMID- 24023416 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20130911 LR - 20211021 IS - 0973-2063 (Print) IS - 0973-2063 (Electronic) IS - 0973-2063 (Linking) VI - 9 IP - 15 DP - 2013 TI - Comparative insights using the molecular homology model of BDNF (Brain derived neurotrophic factor) of Varanus komodoensis and the known NGF (Nerve growth factor) structure of Naja atra. PG - 755-8 LID - 10.6026/97320630009755 [doi] AB - BDNF (Brain derived neurotrophic factor) is a secretion protein and a member of the neurotrophin family of growth factors. Structural and functional characterization of BDNF Varanus komodoensis is of interest while its structure remains unknown. Thus, a homology molecular model of BDNF was constructed for gleaning possible structural insights. The model was compared with the structure of the homologous NGF (Nerve growth factor, another member of neuro-trophin family) from Naja atra. Comparative structural analysis of the models showed structural similarities with their predicted cavities for the interpretation of potential functional analogy. FAU - Verma, Ankit AU - Verma A AD - Bioinformatics Infrastructure Facility, Gauhati University, Guwahati - 781014, Assam, India. FAU - Sharma, Dhirendra Kumar AU - Sharma DK FAU - Sarma, Rituparna AU - Sarma R FAU - Chetia, Hasnahana AU - Chetia H FAU - Saikia, Juri AU - Saikia J LA - eng PT - Journal Article DEP - 20130828 PL - Singapore TA - Bioinformation JT - Bioinformation JID - 101258255 PMC - PMC3766306 EDAT- 2013/09/12 06:00 MHDA- 2013/09/12 06:01 PMCR- 2013/01/01 CRDT- 2013/09/12 06:00 PHST- 2013/08/07 00:00 [received] PHST- 2013/08/08 00:00 [accepted] PHST- 2013/09/12 06:00 [entrez] PHST- 2013/09/12 06:00 [pubmed] PHST- 2013/09/12 06:01 [medline] PHST- 2013/01/01 00:00 [pmc-release] AID - 97320630009755 [pii] AID - 10.6026/97320630009755 [doi] PST - epublish SO - Bioinformation. 2013 Aug 28;9(15):755-8. doi: 10.6026/97320630009755. eCollection 2013.