PMID- 24023568
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130911
LR  - 20211021
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2013
DP  - 2013
TI  - Multivariate granger causality analysis of acupuncture effects in mild cognitive 
      impairment patients: an FMRI study.
PG  - 127271
LID - 10.1155/2013/127271 [doi]
LID - 127271
AB  - Evidence from clinical reports has indicated that acupuncture has a promising 
      effect on mild cognitive impairment (MCI). However, it is still unknown that by 
      what way acupuncture can modulate brain networks involving the MCI. In the 
      current study, multivariate Granger causality analysis (mGCA) was adopted to 
      compare the interregional effective connectivity of brain networks by varying 
      needling depths (deep acupuncture, DA; superficial acupuncture, SA) and at 
      different cognitive states, which were the MCI and healthy control (HC). Results 
      from DA at KI3 in MCI showed that the dorsolateral prefrontal cortex and 
      hippocampus emerged as central hubs and had significant causal influences with 
      each other, but significant in HC for DA. Moreover, only several brain regions 
      had remarkable causal interactions following SA in MCI and even few brain regions 
      following SA in HC. Our results indicated that acupuncture at KI3 at different 
      cognitive states and with varying needling depths may induce distinct 
      reorganizations of effective connectivities of brain networks, and DA at KI3 in 
      MCI can induce the strongest and more extensive effective connectivities related 
      to the therapeutic effect of acupuncture in MCI. The study demonstrated the 
      relatively functional specificity of acupuncture at KI3 in MCI, and needling 
      depths play an important role in acupuncture treatments.
FAU - Chen, Shangjie
AU  - Chen S
AD  - Baoan Hospital, Southern Medical University, Shenzhen 518101, China.
FAU - Bai, Lijun
AU  - Bai L
FAU - Xu, Maosheng
AU  - Xu M
FAU - Wang, Fang
AU  - Wang F
FAU - Yin, Liang
AU  - Yin L
FAU - Peng, Xuming
AU  - Peng X
FAU - Chen, Xinghua
AU  - Chen X
FAU - Shi, Xuemin
AU  - Shi X
LA  - eng
PT  - Journal Article
DEP - 20130819
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC3760118
EDAT- 2013/09/12 06:00
MHDA- 2013/09/12 06:01
PMCR- 2013/08/19
CRDT- 2013/09/12 06:00
PHST- 2013/02/21 00:00 [received]
PHST- 2013/04/11 00:00 [revised]
PHST- 2013/06/02 00:00 [accepted]
PHST- 2013/09/12 06:00 [entrez]
PHST- 2013/09/12 06:00 [pubmed]
PHST- 2013/09/12 06:01 [medline]
PHST- 2013/08/19 00:00 [pmc-release]
AID - 10.1155/2013/127271 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2013;2013:127271. doi: 10.1155/2013/127271. 
      Epub 2013 Aug 19.