PMID- 24024131
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130911
LR  - 20211021
IS  - 2212-8778 (Print)
IS  - 2212-8778 (Electronic)
IS  - 2212-8778 (Linking)
VI  - 2
IP  - 1
DP  - 2013
TI  - Ghrelin regulates hypothalamic prolyl carboxypeptidase expression in mice.
PG  - 23-30
LID - 10.1016/j.molmet.2013.01.002 [doi]
AB  - Hypothalamic Prolyl carboxypeptidase (PRCP) plays a role in the regulation of 
      energy metabolism by inactivating hypothalamic alpha-melanocyte stimulating hormone 
      (alpha-MSH) levels and thus affecting melanocortin signaling. Alpha-MSH production is 
      highly regulated both at transcriptional and posttranslational levels. Here we 
      show that fasting induces a hypothalamic-specific up-regulation of Prcp mRNA and 
      protein levels. Since fasting is characterized by elevated circulating ghrelin 
      levels, we tested the effect of peripheral and central administration of ghrelin, 
      and found that ghrelin increases hypothalamic Prcp mRNA expression. No changes in 
      Prcp mRNA levels were detected in ghrelin knockout mice compared to their 
      controls. Finally, ghrelin effect on PRCP expression was ghrelin 
      receptor-mediated. Altogether our data show that ghrelin is a key regulator of 
      hypothalamic PRCP expression, and up-regulation of PRCP by ghrelin may be an 
      additional mechanism to decrease melanocortin signaling.
FAU - Kwon Jeong, Jin
AU  - Kwon Jeong J
AD  - Program in Integrative Cell Signaling and Neurobiology of Metabolism, New Haven, 
      CT, 06520, USA ; Department of Ob/Gyn & Reproductive Sciences, New Haven, CT, 
      06520, USA.
FAU - Dae Kim, Jung
AU  - Dae Kim J
FAU - Diano, Sabrina
AU  - Diano S
LA  - eng
GR  - R01 DK084065/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20130111
PL  - Germany
TA  - Mol Metab
JT  - Molecular metabolism
JID - 101605730
PMC - PMC3757664
OTO - NOTNLM
OT  - (ARC), Arcuate nucleus
OT  - (AgRP), Agouti related peptide
OT  - (CTX), Cortex
OT  - (DMH), Dorsomedial nucleus
OT  - (GHS-R), Growth hormone secretagogue receptor
OT  - (Hcrt), Hypocretin
OT  - (LH), Lateral hypothalamus
OT  - (MCH), Melanin concentrating hormone
OT  - (NPY), Neuropeptide Y
OT  - (POMC), Proopiomelanocortin
OT  - (PRCP), Prolyl carboxypeptidase
OT  - (Prcpgt/gt), Prcp-ablated mice
OT  - (VMH), Ventromedial nucleus
OT  - (alpha-MSH), alpha-Melanocyte stimulating hormone
OT  - Alpha-melanocyte stimulating hormone
OT  - Fasting
OT  - Ghrelin
OT  - Hypothalamus
OT  - Prolyl carboxypeptidase
EDAT- 2013/09/12 06:00
MHDA- 2013/09/12 06:01
PMCR- 2013/01/11
CRDT- 2013/09/12 06:00
PHST- 2012/12/11 00:00 [received]
PHST- 2012/12/28 00:00 [revised]
PHST- 2013/01/03 00:00 [accepted]
PHST- 2013/09/12 06:00 [entrez]
PHST- 2013/09/12 06:00 [pubmed]
PHST- 2013/09/12 06:01 [medline]
PHST- 2013/01/11 00:00 [pmc-release]
AID - MOLMET25 [pii]
AID - 10.1016/j.molmet.2013.01.002 [doi]
PST - epublish
SO  - Mol Metab. 2013 Jan 11;2(1):23-30. doi: 10.1016/j.molmet.2013.01.002. eCollection 
      2013.