PMID- 24026618
OWN - NLM
STAT- MEDLINE
DCOM- 20140530
LR  - 20211021
IS  - 1559-1166 (Electronic)
IS  - 0895-8696 (Linking)
VI  - 51
IP  - 2
DP  - 2013 Oct
TI  - Association of endothelin-converting enzyme-1b C-338A polymorphism with increased 
      risk of ischemic stroke in Chinese Han population.
PG  - 485-92
LID - 10.1007/s12031-013-0100-y [doi]
AB  - Endothelin-converting enzyme-1b (ECE-1b) C-338A is a polymorphism located in 
      ECE-1 gene promoter, which has been reported to correlate with the risk of 
      carotid atherosclerosis. We conducted a hospital-based case-control study of 309 
      patients with ischemic stroke and 309 controls matched on age and gender. The 
      frequencies of ECE-1b-338 CC, CA, and AA genotypes in cases (45.0, 40.4, and 14.6 
      %) were significantly different from those of controls (53.1, 39.1, and 7.8 %, 
      chi(2) = 8.519, P = 0.014), respectively. Compared with C carriers, A alleles 
      showed correlation with a 42 % increased risk of ischemic stroke (adjusted odds 
      ratio (OR) = 1.42, 95 % CI = 1.11-1.81). After adjustment for potential risk 
      factors, the AA genotype still kept positive correlation with ischemic stroke (OR 
      = 1.78; 95 % CI = 1.06-3.54). In stratified analyses, the significant association 
      of the A allele with ischemic stroke was observed in female subjects (adjusted OR 
      = 1.64, 95 % CI = 1.17-2.89) and the subjects with age >/= 64 years old (adjusted 
      OR = 2.09, 95 % CI = 1.38-3.23). The present study suggested that the C-338A 
      polymorphism of the ECE-1b gene was associated with an increased risk of ischemic 
      stroke in the Chinese Han population.
FAU - Li, Rui
AU  - Li R
AD  - Graduate School, Bengbu Medical College, Bengbu, Anhui, 233004, China.
FAU - Cui, Min
AU  - Cui M
FAU - Zhao, Jin
AU  - Zhao J
FAU - Yu, Mingming
AU  - Yu M
FAU - Ying, Zegang
AU  - Ying Z
FAU - Zhou, Shiming
AU  - Zhou S
FAU - Zhou, Huadong
AU  - Zhou H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130913
PL  - United States
TA  - J Mol Neurosci
JT  - Journal of molecular neuroscience : MN
JID - 9002991
RN  - EC 3.4.23.- (Aspartic Acid Endopeptidases)
RN  - EC 3.4.24.- (Metalloendopeptidases)
RN  - EC 3.4.24.71 (ECE1 protein, human)
RN  - EC 3.4.24.71 (Endothelin-Converting Enzymes)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Alleles
MH  - Aspartic Acid Endopeptidases/*genetics
MH  - Brain Ischemia/diagnosis/*genetics
MH  - Case-Control Studies
MH  - China
MH  - Endothelin-Converting Enzymes
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Heterozygote
MH  - Humans
MH  - Male
MH  - Metalloendopeptidases/*genetics
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Sex Factors
MH  - Stroke/diagnosis/*genetics
EDAT- 2013/09/13 06:00
MHDA- 2014/05/31 06:00
CRDT- 2013/09/13 06:00
PHST- 2013/07/02 00:00 [received]
PHST- 2013/08/14 00:00 [accepted]
PHST- 2013/09/13 06:00 [entrez]
PHST- 2013/09/13 06:00 [pubmed]
PHST- 2014/05/31 06:00 [medline]
AID - 10.1007/s12031-013-0100-y [doi]
PST - ppublish
SO  - J Mol Neurosci. 2013 Oct;51(2):485-92. doi: 10.1007/s12031-013-0100-y. Epub 2013 
      Sep 13.