PMID- 24027334
OWN - NLM
STAT- MEDLINE
DCOM- 20140108
LR  - 20231213
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Print)
IS  - 0022-538X (Linking)
VI  - 87
IP  - 23
DP  - 2013 Dec
TI  - Gamma interferon regulates contraction of the influenza virus-specific CD8 T cell 
      response and limits the size of the memory population.
PG  - 12510-22
LID - 10.1128/JVI.01776-13 [doi]
AB  - The factors that regulate the contraction of the CD8 T cell response and the 
      magnitude of the memory cell population against localized mucosal infections such 
      as influenza are important for generation of efficient vaccines but are currently 
      undefined. In this study, we used a mouse model of influenza to demonstrate that 
      the absence of gamma interferon (IFN-gamma) or IFN-gamma receptor 1 (IFN-gammaR1) leads to 
      aberrant contraction of antigen-specific CD8 T cell responses. The increased 
      accumulation of the effector CD8 T cell population was independent of viral load. 
      Reduced contraction was associated with an increased fraction of CD8 T cells 
      expressing the interleukin-7 receptor (IL-7R) at the peak of the response, 
      resulting in enhanced numbers of memory/memory precursor cells in IFN-gamma(-/-) and 
      IFN-gammaR(-/-) compared to wild-type (WT) mice. Blockade of IL-7 within the lungs of 
      IFN-gamma(-/-) mice restored the contraction of influenza virus-specific CD8 T cells, 
      indicating that IL-7R is important for survival and is not simply a consequence 
      of the lack of IFN-gamma signaling. Finally, enhanced CD8 T cell recall responses and 
      accelerated viral clearance were observed in the IFN-gamma(-/-) and IFN-gammaR(-/-) mice 
      after rechallenge with a heterologous strain of influenza virus, confirming that 
      higher frequencies of memory precursors are formed in the absence of IFN-gamma 
      signaling. In summary, we have identified IFN-gamma as an important regulator of 
      localized viral immunity that promotes the contraction of antigen-specific CD8 T 
      cells and inhibits memory precursor formation, thereby limiting the size of the 
      memory cell population after an influenza virus infection.
FAU - Prabhu, Nayana
AU  - Prabhu N
AD  - Immunology Programme and Department of Microbiology, National University of 
      Singapore, Singapore.
FAU - Ho, Adrian W
AU  - Ho AW
FAU - Wong, Kenneth H S
AU  - Wong KH
FAU - Hutchinson, Paul Edward
AU  - Hutchinson PE
FAU - Chua, Yen Leong
AU  - Chua YL
FAU - Kandasamy, Matheswaran
AU  - Kandasamy M
FAU - Lee, Debbie C P
AU  - Lee DC
FAU - Sivasankar, Baalasubramanian
AU  - Sivasankar B
FAU - Kemeny, David Michael
AU  - Kemeny DM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130911
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Receptors, Interferon)
RN  - 0 (Receptors, Interleukin-7)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - CD8-Positive T-Lymphocytes/cytology/*immunology
MH  - Female
MH  - Humans
MH  - *Immunologic Memory
MH  - Influenza A virus/genetics/*immunology
MH  - Influenza, Human/genetics/*immunology/virology
MH  - Interferon-gamma/deficiency/genetics/*immunology
MH  - Lymphocyte Count
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Receptors, Interferon/deficiency/genetics/immunology
MH  - Receptors, Interleukin-7/genetics/immunology
MH  - Species Specificity
MH  - Interferon gamma Receptor
PMC - PMC3838152
EDAT- 2013/09/13 06:00
MHDA- 2014/01/09 06:00
PMCR- 2014/06/01
CRDT- 2013/09/13 06:00
PHST- 2013/09/13 06:00 [entrez]
PHST- 2013/09/13 06:00 [pubmed]
PHST- 2014/01/09 06:00 [medline]
PHST- 2014/06/01 00:00 [pmc-release]
AID - JVI.01776-13 [pii]
AID - 01776-13 [pii]
AID - 10.1128/JVI.01776-13 [doi]
PST - ppublish
SO  - J Virol. 2013 Dec;87(23):12510-22. doi: 10.1128/JVI.01776-13. Epub 2013 Sep 11.