PMID- 2402776
OWN - NLM
STAT- MEDLINE
DCOM- 19901024
LR  - 20220321
IS  - 0041-1132 (Print)
IS  - 0041-1132 (Linking)
VI  - 30
IP  - 7
DP  - 1990 Sep
TI  - Alloimmunization to platelet-specific antigens on glycoproteins IIb-IIIa and 
      Ib/IX in multiply transfused thrombocytopenic patients.
PG  - 622-5
AB  - The rate of alloimmunization to platelet-specific antigens associated with 
      platelet glycoproteins (GPs) IIb-IIIa and Ib/IX was studied in 293 multiply 
      transfused thrombocytopenic patients. Antibodies to platelet-specific antigens 
      were measured with a solid-phase assay using platelet GP IIb-IIIa or Ib/IX as the 
      antigenic targets. Nine patients were found to have antibodies to platelet GP 
      IIb-IIIa, and no patients had antibodies to platelet GP Ib/IX. In six of these 
      nine patients, the specificity of the antibody was shown by using GP IIb-IIIa 
      from donors with different platelet-specific antigen phenotypes. In the remaining 
      three patients with antibodies to platelet GP IIb-IIIa, no specificity could be 
      identified. These patients had autoimmune thrombocytopenia in association with 
      lymphoma. The alloimmunization rate to platelet-specific antigens associated with 
      GP IIb-IIIa was 2 percent, whereas the rate of alloimmunization to HLA antigens 
      was 23 percent. Of the patients alloimmunized to HLA antigens, 9 percent also had 
      antibodies to platelet-specific antigens. A poor response to HLA-identical 
      platelet transfusions was observed only in those patients with positive assays in 
      the solid-phase test. These results suggest that the incidence of antibodies to 
      platelet-specific antigens carried on GP IIb-IIIa is low. Platelet-specific 
      antibodies may be found more frequently in patients alloimmunized to HLA antigens 
      than in those not so alloimmunized.
FAU - Kickler, T
AU  - Kickler T
AD  - Department of Laboratory Medicine, Johns Hopkins Hospital, Baltimore, Maryland.
FAU - Kennedy, S D
AU  - Kennedy SD
FAU - Braine, H G
AU  - Braine HG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
RN  - 0 (3a alloantigen, human)
RN  - 0 (4a alloantigen, human)
RN  - 0 (5b alloantigen, human)
RN  - 0 (Antigens, Human Platelet)
RN  - 0 (ITGB3 protein, human)
RN  - 0 (Integrin beta3)
RN  - 0 (Isoantibodies)
RN  - 0 (Isoantigens)
RN  - 0 (Platelet Membrane Glycoproteins)
SB  - IM
MH  - *Antigens, Human Platelet
MH  - Biological Assay
MH  - Blood Transfusion
MH  - Female
MH  - Humans
MH  - *Immunization
MH  - Integrin beta3
MH  - Isoantibodies/*immunology
MH  - Isoantigens/*immunology
MH  - Male
MH  - Platelet Membrane Glycoproteins/*immunology
MH  - Thrombocytopenia/*blood/immunology/therapy
EDAT- 1990/09/01 00:00
MHDA- 1990/09/01 00:01
CRDT- 1990/09/01 00:00
PHST- 1990/09/01 00:00 [pubmed]
PHST- 1990/09/01 00:01 [medline]
PHST- 1990/09/01 00:00 [entrez]
AID - 10.1046/j.1537-2995.1990.30790385520.x [doi]
PST - ppublish
SO  - Transfusion. 1990 Sep;30(7):622-5. doi: 10.1046/j.1537-2995.1990.30790385520.x.