PMID- 24029438
OWN - NLM
STAT- MEDLINE
DCOM- 20140605
LR  - 20221207
IS  - 1678-4391 (Electronic)
IS  - 1413-8670 (Print)
IS  - 1413-8670 (Linking)
VI  - 18
IP  - 1
DP  - 2014 Jan-Feb
TI  - The association of HLA-DRB1 alleles and drug use with HIV infection in a Chinese 
      Han Cohort.
PG  - 82-7
LID - S1413-8670(13)00195-5 [pii]
LID - 10.1016/j.bjid.2013.04.007 [doi]
AB  - OBJECTIVE: To investigate the relationship between the polymorphism of human 
      leukocyte antigen (HLA)-DRB1 and the susceptibility and repellency of drug use 
      combined with HIV infection in Chinese. METHODS: A total of 213 unrelated healthy 
      people, 41 HIV-infected drug users, 24 HIV-uninfected drug users, and 64 
      HIV-infected non-drug users were recruited. Their HLA-DRB1 allele frequencies 
      were analyzed by PCR-SSP and allele distribution was analyzed. RESULTS: Compared 
      with healthy controls, in drug users, the frequencies of HLA-DRB1 *0401-041, 
      *1001 were significantly higher; in HIV-infected patients, the frequencies of 
      HLA-DRB1 *0101-0103, *0401-0411, *1001 were significantly higher, while the 
      frequencies of DRB1 *1501-1502, *1101-1105, *1301-1302, DRB4, DRB5 were 
      significantly lower; in HIV-infected drug users, the frequencies of HLA-DRB1 
      *0101-0103, *0401-0411, *0801-0806, *1001, *1401/1404/1405 were significantly 
      higher, while the frequencies of DRB1 *1301/1302, 1501-1502, DRB5 were 
      significantly lower. CONCLUSION: There is close relationship between the 
      polymorphism of HLA-DRB1 alleles and drug use with HIV infection, which plays an 
      important role in elucidating the pathogenesis and providing the basis for 
      therapeutics and prophylaxis of patients with drug use and HIV infection.
CI  - Copyright (c) 2013. Published by Elsevier Editora Ltda.
FAU - Diao, Bo
AU  - Diao B
AD  - State Key Laboratory of Virology/Institute of Virology, School of Medicine, Wuhan 
      University, Wuhan, China; Department of Neurosurgery, Wuhan General Hospital 
      Guangzhou Military Region, Wuhan, China.
FAU - Du, Juan
AU  - Du J
AD  - Department of Nephrology, Renmin hospital of Wuhan University, Wuhan, China.
FAU - Liu, Ying
AU  - Liu Y
AD  - Department of Clinical Laboratory, Wuhan General Hospital Guangzhou Military 
      Region, Wuhan, China.
FAU - Luo, Fan
AU  - Luo F
AD  - State Key Laboratory of Virology/Institute of Virology, School of Medicine, Wuhan 
      University, Wuhan, China.
FAU - Hou, Wei
AU  - Hou W
AD  - State Key Laboratory of Virology/Institute of Virology, School of Medicine, Wuhan 
      University, Wuhan, China. Electronic address: houwei@whu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130909
PL  - Brazil
TA  - Braz J Infect Dis
JT  - The Brazilian journal of infectious diseases : an official publication of the 
      Brazilian Society of Infectious Diseases
JID - 9812937
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Asian People
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HIV Infections/etiology/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Male
MH  - Polymorphism, Genetic/*genetics
MH  - Substance-Related Disorders/complications/*genetics
PMC - PMC9425253
OTO - NOTNLM
OT  - Drug use combined with HIV infection
OT  - Frequency
OT  - HLA-DRB1
OT  - Polymorphism
EDAT- 2013/09/14 06:00
MHDA- 2014/06/06 06:00
PMCR- 2013/09/09
CRDT- 2013/09/14 06:00
PHST- 2012/10/10 00:00 [received]
PHST- 2013/03/14 00:00 [revised]
PHST- 2013/04/11 00:00 [accepted]
PHST- 2013/09/14 06:00 [entrez]
PHST- 2013/09/14 06:00 [pubmed]
PHST- 2014/06/06 06:00 [medline]
PHST- 2013/09/09 00:00 [pmc-release]
AID - S1413-8670(13)00195-5 [pii]
AID - 10.1016/j.bjid.2013.04.007 [doi]
PST - ppublish
SO  - Braz J Infect Dis. 2014 Jan-Feb;18(1):82-7. doi: 10.1016/j.bjid.2013.04.007. Epub 
      2013 Sep 9.