PMID- 24030807
OWN - NLM
STAT- MEDLINE
DCOM- 20140905
LR  - 20171116
IS  - 2567-689X (Electronic)
IS  - 0340-6245 (Linking)
VI  - 110
IP  - 6
DP  - 2013 Dec
TI  - Effects of high-amount-high-intensity exercise on in vivo platelet activation: 
      modulation by lipid peroxidation and AGE/RAGE axis.
PG  - 1232-40
LID - 10.1160/TH13-04-0295 [doi]
AB  - Physical activity is associated with cardiovascular risk reduction, but the 
      effects of exercise on platelet activation remain controversial. We investigated 
      the effects of regular high-amount, high intensity aerobic exercise on in vivo 
      thromboxane (TX)-dependent platelet activation and plasma levels of 
      platelet-derived proteins, CD40L and P-selectin, and whether platelet variables 
      changes may be related to changes in high-density lipoprotein (HDL) and in the 
      extent of oxidative stress and oxidative stress-related inflammation, as 
      reflected by urinary isoprostane excretion and endogenous soluble receptor for 
      advanced glycation end-products (esRAGE), respectively. Urinary excretion of 
      11-dehydro-TXB(2) and 8-iso-prostaglandin (PG)F(2alpha) and plasma levels of 
      P-selectin, CD40L and esRAGE were measured before and after a eight-week 
      standardised aerobic high-amount-high-intensity training program in 22 sedentary 
      subjects with low-to-intermediate risk. Exercise training had a clear beneficial 
      effect on HDL cholesterol (+10%, p=0.027) and triglyceride (-27%, p=0.008) 
      concentration. In addition, a significant (p<0.0001) decrease in urinary 
      11-dehydro-TXB(2) (26%), 8-iso-PGF(2alpha) (21%), plasma P-selectin (27%), CD40L (35%) 
      and a 61% increase in esRAGE were observed. Multiple regression analysis revealed 
      that urinary 8-iso-PGF(2alpha) [beta=0.33, SEM=0.116, p=0.027] and esRAGE 
      (beta=-0.30, SEM=31.3, p=0.046) were the only significant predictors of urinary 
      11-dehydro-TXB(2) excretion rate over the training period. In conclusion, regular 
      high-amount-high-intensity exercise training has broad beneficial effects on 
      platelet activation markers, paralleled and possibly associated with changes in 
      the lipoprotein profile and in markers of lipid peroxidation and AGE/RAGE axis. 
      Our findings may help explaining why a similar amount of exercise exerts 
      significant benefits in preventing cardiovascular events.
FAU - Santilli, Francesca
AU  - Santilli F
AD  - Giovanni Davi, Center of Excellence on Aging, "G. D'Annunzio" University 
      Foundation, Via Colle dell'Ara, 66013 Chieti, Italy, Tel.: +39 0871 541312, Fax: 
      +39 0871 541261, E-mail: gdavi@unich.it.
FAU - Vazzana, Natale
AU  - Vazzana N
FAU - Iodice, Pierpaolo
AU  - Iodice P
FAU - Lattanzio, Stefano
AU  - Lattanzio S
FAU - Liani, Rossella
AU  - Liani R
FAU - Bellomo, Rosa Grazia
AU  - Bellomo RG
FAU - Lessiani, Gianfranco
AU  - Lessiani G
FAU - Perego, Francesca
AU  - Perego F
FAU - Saggini, Raoul
AU  - Saggini R
FAU - Davi, Giovanni
AU  - Davi G
LA  - eng
PT  - Journal Article
DEP - 20130912
PL  - Germany
TA  - Thromb Haemost
JT  - Thrombosis and haemostasis
JID - 7608063
RN  - 0 (Glycation End Products, Advanced)
RN  - 0 (Isoprostanes)
RN  - 0 (Lipoproteins, HDL)
RN  - 0 (P-Selectin)
RN  - 0 (Receptor for Advanced Glycation End Products)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Thromboxanes)
RN  - 147205-72-9 (CD40 Ligand)
RN  - 54397-85-2 (Thromboxane B2)
RN  - 67910-12-7 (11-dehydro-thromboxane B2)
SB  - IM
MH  - Aged
MH  - Blood Platelets/*metabolism
MH  - CD40 Ligand/blood
MH  - *Exercise/physiology
MH  - Female
MH  - Glycation End Products, Advanced
MH  - Humans
MH  - Isoprostanes/*urine
MH  - Lipid Peroxidation/physiology
MH  - Lipoproteins, HDL/metabolism
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress
MH  - P-Selectin/blood
MH  - Platelet Activation/physiology
MH  - Receptor for Advanced Glycation End Products
MH  - Receptors, Immunologic/*blood
MH  - Thromboxane B2/*analogs & derivatives/urine
MH  - Thromboxanes/metabolism
OTO - NOTNLM
OT  - Aerobic exercise
OT  - esRAGE
OT  - oxidative stress
OT  - platelet activation
EDAT- 2013/09/14 06:00
MHDA- 2014/09/06 06:00
CRDT- 2013/09/14 06:00
PHST- 2013/04/11 00:00 [received]
PHST- 2013/08/09 00:00 [accepted]
PHST- 2013/09/14 06:00 [entrez]
PHST- 2013/09/14 06:00 [pubmed]
PHST- 2014/09/06 06:00 [medline]
AID - 13-04-0295 [pii]
AID - 10.1160/TH13-04-0295 [doi]
PST - ppublish
SO  - Thromb Haemost. 2013 Dec;110(6):1232-40. doi: 10.1160/TH13-04-0295. Epub 2013 Sep 
      12.