PMID- 24033084
OWN - NLM
STAT- MEDLINE
DCOM- 20140915
LR  - 20181203
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 82
IP  - 4
DP  - 2013 Oct
TI  - Genetic polymorphism of KIR2DL4 (CD158d), a putative NK cell receptor for HLA-G, 
      does not influence susceptibility to asthma.
PG  - 276-9
LID - 10.1111/tan.12185 [doi]
AB  - Human leukocyte antigen (HLA)-G is upregulated on the bronchial epithelium of 
      asthma patients and genetic polymorphism affecting expression of HLA-G has been 
      reported to influence susceptibility to asthma. As the NK cell receptor KIR2DL4 
      has been reported to induce interferon gamma (IFNgamma) secretion when ligated with 
      HLA-G, we postulated that the 9A/10A genetic polymorphism of KIR2DL4 which 
      influences receptor structure may influence susceptibility to asthma. KIR2DL4 
      genotypes were determined in two cohorts of children (n = 219 and n = 1356) in 
      whom total serum IgE, allergen-specific IgE, atopy, bronchial reactivity and 
      asthma symptoms had been studied between birth and 14 years. No reproducible 
      associations with KIR2DL4 genotype were identified, leading us to conclude that 
      the KIR2DL4 9A/10A polymorphism has no influence on susceptibility to asthma.
CI  - (c) 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Le Page, M E L
AU  - Le Page ME
AD  - School of Pathology and Laboratory Medicine, University of Western Australia, 
      Perth, WA,, Australia.
FAU - Goodridge, J P
AU  - Goodridge JP
FAU - Zhang, G
AU  - Zhang G
FAU - Holt, P G
AU  - Holt PG
FAU - Sly, P
AU  - Sly P
FAU - Witt, C S
AU  - Witt CS
LA  - eng
PT  - Journal Article
DEP - 20130823
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-G Antigens)
RN  - 0 (KIR2DL4 protein, human)
RN  - 0 (Receptors, KIR2DL4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adolescent
MH  - Asthma/blood/*genetics/immunology/pathology
MH  - Bronchial Hyperreactivity/blood/*genetics/immunology/pathology
MH  - Child
MH  - Child, Preschool
MH  - Disease Susceptibility
MH  - Female
MH  - HLA-G Antigens/*genetics/immunology
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Interferon-gamma/metabolism
MH  - Killer Cells, Natural/immunology/pathology
MH  - Longitudinal Studies
MH  - Male
MH  - *Polymorphism, Genetic
MH  - Receptors, KIR2DL4/*genetics/immunology
MH  - Respiratory Mucosa/immunology/metabolism/pathology
OTO - NOTNLM
OT  - CD158d
OT  - KIR2DL4
OT  - asthma
OT  - atopy
EDAT- 2013/09/17 06:00
MHDA- 2014/09/16 06:00
CRDT- 2013/09/17 06:00
PHST- 2013/02/06 00:00 [received]
PHST- 2013/07/07 00:00 [revised]
PHST- 2013/07/19 00:00 [accepted]
PHST- 2013/09/17 06:00 [entrez]
PHST- 2013/09/17 06:00 [pubmed]
PHST- 2014/09/16 06:00 [medline]
AID - 10.1111/tan.12185 [doi]
PST - ppublish
SO  - Tissue Antigens. 2013 Oct;82(4):276-9. doi: 10.1111/tan.12185. Epub 2013 Aug 23.