PMID- 24035333
OWN - NLM
STAT- MEDLINE
DCOM- 20131212
LR  - 20191210
IS  - 1879-355X (Electronic)
IS  - 0360-3016 (Linking)
VI  - 87
IP  - 4
DP  - 2013 Nov 15
TI  - Hyperbaric oxygen treatment in radiation-induced cystitis and proctitis: a 
      prospective cohort study on patient-perceived quality of recovery.
PG  - 670-5
LID - S0360-3016(13)02911-8 [pii]
LID - 10.1016/j.ijrobp.2013.07.039 [doi]
AB  - PURPOSE: In this prospective cohort study, the effects of hyperbaric oxygen 
      treatment (HBOT) were evaluated concerning patient-perceived symptoms of late 
      radiation-induced cystitis and proctitis secondary to radiation therapy for 
      pelvic cancer. METHODS AND MATERIALS: Thirty-nine patients, 35 men and 4 women 
      with a mean age of 71 (range, 35-84) years were included after informed consent 
      and institutional ethics approval. They had all been treated with radiation 
      therapy for prostate (n=34), cervix (n=2), or rectal (n=3) cancer using external 
      beam radiation at a dose of 25 to 75 Gy. Patients with hematuria requiring blood 
      transfusion were excluded. The HBOT was delivered with 100% oxygen for 90 minutes 
      at 2.0 to 2.4 atmospheres (ATA). Mean number of treatments was 36 (28-40). 
      Symptoms were prospectively assessed using the Expanded Prostate Index Composite 
      score before, during, and 6 to 12 months after HBOT. RESULTS: The HBOT was 
      successfully conducted, and symptoms were alleviated in 76% for patients with 
      radiation cystitis, 89% for patients with radiation proctitis, and 88% of 
      patients with combined cystitis and proctitis. Symptom reduction was demonstrated 
      by an increased Expanded Prostate Index Composite score in the urinary domain 
      from 50+/-16 to 66+/-20 after treatment (P<.001) and in the bowel domain from 48+/-18 
      to 68+/-18 after treatment (P<.001). For 31% of the patients with cystitis and 22% 
      with proctitis, there were only trivial symptoms after HBOT. The improvement was 
      sustained at follow-up in both domains 6 to 12 months after HBOT. No severe side 
      effects were observed related to HBOT, and treatment compliance was high. 
      CONCLUSIONS: HBOT can be an effective and safe treatment modality for late 
      radiation therapy-induced soft tissue injuries in the pelvic region.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Oscarsson, Nicklas
AU  - Oscarsson N
AD  - Department of Anaesthesiology and Intensive Care Medicine, Sahlgrenska Academy, 
      University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden. 
      Electronic address: nicklas.oscarsson@vgregion.se.
FAU - Arnell, Per
AU  - Arnell P
FAU - Lodding, Par
AU  - Lodding P
FAU - Ricksten, Sven-Erik
AU  - Ricksten SE
FAU - Seeman-Lodding, Helene
AU  - Seeman-Lodding H
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20130911
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Cystitis/etiology/*therapy
MH  - *Diagnostic Self Evaluation
MH  - Female
MH  - Humans
MH  - Hyperbaric Oxygenation/*methods
MH  - Male
MH  - Middle Aged
MH  - Patient Compliance/statistics & numerical data
MH  - Proctitis/etiology/*therapy
MH  - Prospective Studies
MH  - Prostatic Neoplasms/radiotherapy
MH  - Radiation Injuries/complications/*therapy
MH  - Radiotherapy Dosage
MH  - *Recovery of Function
MH  - Rectal Neoplasms/radiotherapy
MH  - Surveys and Questionnaires
MH  - Uterine Cervical Neoplasms/radiotherapy
EDAT- 2013/09/17 06:00
MHDA- 2013/12/18 06:00
CRDT- 2013/09/17 06:00
PHST- 2013/05/11 00:00 [received]
PHST- 2013/07/14 00:00 [revised]
PHST- 2013/07/30 00:00 [accepted]
PHST- 2013/09/17 06:00 [entrez]
PHST- 2013/09/17 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - S0360-3016(13)02911-8 [pii]
AID - 10.1016/j.ijrobp.2013.07.039 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2013 Nov 15;87(4):670-5. doi: 
      10.1016/j.ijrobp.2013.07.039. Epub 2013 Sep 11.