PMID- 24035414
OWN - NLM
STAT- MEDLINE
DCOM- 20131203
LR  - 20211021
IS  - 1878-1551 (Electronic)
IS  - 1534-5807 (Print)
IS  - 1534-5807 (Linking)
VI  - 26
IP  - 6
DP  - 2013 Sep 30
TI  - Adrenocortical zonation results from lineage conversion of differentiated zona 
      glomerulosa cells.
PG  - 666-673
LID - 10.1016/j.devcel.2013.07.016 [doi]
AB  - Lineage conversion of differentiated cells in response to hormonal feedback has 
      yet to be described. To investigate this, we studied the adrenal cortex, which is 
      composed of functionally distinct concentric layers that develop postnatally, the 
      outer zona glomerulosa (zG) and the inner zona fasciculata (zF). These layers 
      have separate functions, are continuously renewed in response to physiological 
      demands, and are regulated by discrete hormonal feedback loops. Their cellular 
      origin, lineage relationship, and renewal mechanism, however, remain poorly 
      understood. Cell-fate mapping and gene-deletion studies using zG-specific Cre 
      expression demonstrate that differentiated zG cells undergo lineage conversion 
      into zF cells. In addition, zG maintenance is dependent on the master 
      transcriptional regulator Steroidogenic Factor 1 (SF-1), and zG-specific Sf-1 
      deletion prevents lineage conversion. These findings demonstrate that 
      adrenocortical zonation and regeneration result from lineage conversion and may 
      provide a paradigm for homeostatic cellular renewal in other tissues.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Freedman, Bethany D
AU  - Freedman BD
AD  - Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115 USA.
AD  - Department of Pediatrics, Harvard Medical School, Boston, MA 02115 USA.
FAU - Kempna, Petra Bukovac
AU  - Kempna PB
AD  - Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115 USA.
AD  - Department of Pediatrics, Harvard Medical School, Boston, MA 02115 USA.
FAU - Carlone, Diana L
AU  - Carlone DL
AD  - Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115 USA.
AD  - Department of Pediatrics, Harvard Medical School, Boston, MA 02115 USA.
FAU - Shah, Manasvi
AU  - Shah M
AD  - Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115 USA.
AD  - Department of Pediatrics, Harvard Medical School, Boston, MA 02115 USA.
FAU - Guagliardo, Nick A
AU  - Guagliardo NA
AD  - Department of Pharmacology, University of Virginia School of Medicine, 
      Charlottesville, VA, 22908 USA.
FAU - Barrett, Paula Q
AU  - Barrett PQ
AD  - Department of Pharmacology, University of Virginia School of Medicine, 
      Charlottesville, VA, 22908 USA.
FAU - Gomez-Sanchez, Celso E
AU  - Gomez-Sanchez CE
AD  - Department of Medicine, University of Mississippi Medical Center, Jackson, MS 
      39216 USA.
FAU - Majzoub, Joseph A
AU  - Majzoub JA
AD  - Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115 USA.
AD  - Department of Pediatrics, Harvard Medical School, Boston, MA 02115 USA.
FAU - Breault, David T
AU  - Breault DT
AD  - Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115 USA.
AD  - Department of Pediatrics, Harvard Medical School, Boston, MA 02115 USA.
AD  - Harvard Stem Cell Institute, Cambridge, MA 02138 USA.
LA  - eng
GR  - R01 DK 084056/DK/NIDDK NIH HHS/United States
GR  - R01 DK100653/DK/NIDDK NIH HHS/United States
GR  - P30 HD018655/HD/NICHD NIH HHS/United States
GR  - K08 DK066305/DK/NIDDK NIH HHS/United States
GR  - R01 HL089717/HL/NHLBI NIH HHS/United States
GR  - K08 DK 066305/DK/NIDDK NIH HHS/United States
GR  - T32 DK007699/DK/NIDDK NIH HHS/United States
GR  - R01 HL036977/HL/NHLBI NIH HHS/United States
GR  - R01 DK084056/DK/NIDDK NIH HHS/United States
GR  - P30 HD18655/HD/NICHD NIH HHS/United States
GR  - UL1 TR000077/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130912
PL  - United States
TA  - Dev Cell
JT  - Developmental cell
JID - 101120028
RN  - 0 (Hormones)
RN  - 0 (Steroidogenic Factor 1)
SB  - IM
CIN - Endocrinology. 2013 Dec;154(12):4446-9. PMID: 24273232
MH  - Animals
MH  - Cell Differentiation
MH  - *Cell Lineage
MH  - Embryonic Stem Cells/cytology/metabolism
MH  - Feedback, Physiological
MH  - Gene Deletion
MH  - Gene Expression Regulation, Developmental
MH  - Homeostasis
MH  - Hormones/metabolism
MH  - Mice
MH  - Steroidogenic Factor 1/genetics/metabolism
MH  - Transcription, Genetic
MH  - Zona Fasciculata/*cytology/growth & development/metabolism
MH  - Zona Glomerulosa/*cytology/growth & development/metabolism
PMC - PMC3791142
MID - NIHMS509170
EDAT- 2013/09/17 06:00
MHDA- 2013/12/16 06:00
PMCR- 2014/09/30
CRDT- 2013/09/17 06:00
PHST- 2012/12/06 00:00 [received]
PHST- 2013/06/11 00:00 [revised]
PHST- 2013/07/17 00:00 [accepted]
PHST- 2013/09/17 06:00 [entrez]
PHST- 2013/09/17 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PHST- 2014/09/30 00:00 [pmc-release]
AID - 10.1016/j.devcel.2013.07.016 [doi]
PST - ppublish
SO  - Dev Cell. 2013 Sep 30;26(6):666-673. doi: 10.1016/j.devcel.2013.07.016. Epub 2013 
      Sep 12.