PMID- 24035576
OWN - NLM
STAT- MEDLINE
DCOM- 20140513
LR  - 20131105
IS  - 1471-4981 (Electronic)
IS  - 1471-4906 (Linking)
VI  - 34
IP  - 11
DP  - 2013 Nov
TI  - Innate immune cells in asthma.
PG  - 540-7
LID - S1471-4906(13)00130-0 [pii]
LID - 10.1016/j.it.2013.08.004 [doi]
AB  - Asthma is an inflammatory disease of the airways associated with a T helper (Th)2 
      response. Such a response in the lungs requires complex interactions between 
      innate cells and structural cells. Dendritic cells (DCs) are pivotal during 
      sensitization to allergens but clearly require epithelium-derived signals to 
      become activated. Epithelial cells also contribute to the activation and the 
      survival of mast cells (MCs), basophils, and eosinophils and group 2 innate 
      lymphoid cells (ILC2s). In turn, these innate cells can activate DCs to sustain 
      Th2 immunity. Here, we review the role played by these different populations of 
      immune cells in the pathogenesis of asthma and how they interact to orchestrate 
      Th2 immunity.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Deckers, Julie
AU  - Deckers J
AD  - Laboratory of Immunoregulation and Mucosal Immunology, DMBR-VIB, Zwijnaarde, 
      Belgium; Laboratory of Immunoregulation, Ghent University, Ghent, Belgium; 
      Cytokine Receptor Laboratory, VIB Department of Medical Protein Research, Ghent, 
      Belgium.
FAU - Branco Madeira, Filipe
AU  - Branco Madeira F
FAU - Hammad, Hamida
AU  - Hammad H
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130912
PL  - England
TA  - Trends Immunol
JT  - Trends in immunology
JID - 100966032
SB  - IM
MH  - Animals
MH  - Asthma/*immunology
MH  - Basophils/immunology
MH  - Dendritic Cells/immunology
MH  - Eosinophils/immunology
MH  - Humans
MH  - Immunity, Innate/*immunology
MH  - Lymphocytes/immunology
MH  - Mast Cells/immunology
MH  - Th2 Cells/*immunology
OTO - NOTNLM
OT  - Th2
OT  - asthma
OT  - innate cells
OT  - lung
EDAT- 2013/09/17 06:00
MHDA- 2014/05/14 06:00
CRDT- 2013/09/17 06:00
PHST- 2013/06/17 00:00 [received]
PHST- 2013/08/12 00:00 [revised]
PHST- 2013/08/13 00:00 [accepted]
PHST- 2013/09/17 06:00 [entrez]
PHST- 2013/09/17 06:00 [pubmed]
PHST- 2014/05/14 06:00 [medline]
AID - S1471-4906(13)00130-0 [pii]
AID - 10.1016/j.it.2013.08.004 [doi]
PST - ppublish
SO  - Trends Immunol. 2013 Nov;34(11):540-7. doi: 10.1016/j.it.2013.08.004. Epub 2013 
      Sep 12.