PMID- 24035904
OWN - NLM
STAT- MEDLINE
DCOM- 20150831
LR  - 20220129
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Print)
IS  - 1047-3211 (Linking)
VI  - 25
IP  - 2
DP  - 2015 Feb
TI  - Object-in-place associative recognition memory depends on glutamate receptor 
      neurotransmission within two defined hippocampal-cortical circuits: a critical 
      role for AMPA and NMDA receptors in the hippocampus, perirhinal, and prefrontal 
      cortices.
PG  - 472-81
LID - 10.1093/cercor/bht245 [doi]
AB  - Object-in-place associative recognition memory depends on an interaction between 
      the hippocampus (HPC), perirhinal (PRH), and medial prefrontal (mPFC) cortices, 
      yet the contribution of glutamate receptor neurotransmission to these 
      interactions is unknown. NMDA receptors (NMDAR) in the HPC were critical for 
      encoding of object-in-place memory but not for single-item object recognition. 
      Next, a disconnection procedure was used to examine the importance of 
      "concurrent" glutamate neurotransmission in the HPC-mPFC and HPC-PRH. 
      Contralateral unilateral infusions of NBQX (AMPAR antagonist), into the HPC-mPFC, 
      or HPC-PRH, either before acquisition or test, impaired object-in-place 
      performance. Thus, both circuits are necessary for encoding and retrieval. 
      Crossed unilateral AP5 (NMDAR antagonist) infusions into the HPC-mPFC or HPC-PRH 
      impaired encoding, but not retrieval. Specifically crossed HPC-mPFC infusions 
      impaired both short-term (5 min) and longer term (1 h) memory while HPC-PRH 
      infusions impaired longer term memory only. This delay-dependent effect of AP5 in 
      the HPC-PRH on object-in-place memory, accords with its effects in the PRH, on 
      single item object recognition memory, thereby suggesting that a single PRH 
      synaptic plasticity mechanism underpins different recognition memory processes. 
      Further, blocking excitatory neurotransmission in any pair of structures within 
      the networks impaired "both" encoding and retrieval, thus object-in-place memory 
      clearly requires network interdependency across multiple structures.
CI  - (c) The Author 2013. Published by Oxford University Press.
FAU - Barker, Gareth Robert Issac
AU  - Barker GR
AD  - MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, 
      University of Bristol, Medical Sciences Building, University Walk, Bristol BS8 
      1TD, UK.
FAU - Warburton, Elizabeth Clea
AU  - Warburton EC
AD  - MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, 
      University of Bristol, Medical Sciences Building, University Walk, Bristol BS8 
      1TD, UK.
LA  - eng
GR  - BB/E010407/1/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
GR  - BB/E010407/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130912
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Quinoxalines)
RN  - 0 (Receptors, AMPA)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 118876-58-7 (2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline)
SB  - IM
MH  - Animals
MH  - Association Learning/drug effects/physiology
MH  - Catheters, Indwelling
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Exploratory Behavior/drug effects/physiology
MH  - Hippocampus/drug effects/*physiology
MH  - Male
MH  - Neural Pathways/drug effects/physiology
MH  - Neuronal Plasticity
MH  - Neuropsychological Tests
MH  - Prefrontal Cortex/drug effects/*physiology
MH  - Quinoxalines/pharmacology
MH  - Rats
MH  - Receptors, AMPA/antagonists & inhibitors/*metabolism
MH  - Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/*metabolism
MH  - Recognition, Psychology/drug effects/*physiology
MH  - Temporal Lobe/drug effects/*physiology
PMC - PMC4380082
OTO - NOTNLM
OT  - brain circuits
OT  - encoding
OT  - glutamate receptors
OT  - plasticity
OT  - retrieval
EDAT- 2013/09/17 06:00
MHDA- 2015/09/01 06:00
PMCR- 2013/09/12
CRDT- 2013/09/17 06:00
PHST- 2013/09/17 06:00 [entrez]
PHST- 2013/09/17 06:00 [pubmed]
PHST- 2015/09/01 06:00 [medline]
PHST- 2013/09/12 00:00 [pmc-release]
AID - bht245 [pii]
AID - 10.1093/cercor/bht245 [doi]
PST - ppublish
SO  - Cereb Cortex. 2015 Feb;25(2):472-81. doi: 10.1093/cercor/bht245. Epub 2013 Sep 
      12.