PMID- 24036849
OWN - NLM
STAT- MEDLINE
DCOM- 20140806
LR  - 20211021
IS  - 1432-1459 (Electronic)
IS  - 0340-5354 (Linking)
VI  - 260
IP  - 12
DP  - 2013 Dec
TI  - Endurance training in MS: short-term immune responses and their relation to 
      cardiorespiratory fitness, health-related quality of life, and fatigue.
PG  - 2993-3001
LID - 10.1007/s00415-013-7091-z [doi]
AB  - The influences of exercise on cytokine response, health-related quality of life 
      (HR-QoL), and fatigue are important aspects of MS rehabilitation. Physical 
      exercises performed within these programs are often practiced in water, but the 
      effects of immersion have not been investigated. To investigate the influences of 
      short-term immune responses and cardiorespiratory fitness on HR-QoL and fatigue 
      during 3 weeks endurance training conducted on a cycle-ergometer or an 
      aquatic-bike. Randomized controlled clinical trial in 60 MS patients. HR-QoL, 
      fatigue, cardiorespiratory fitness, and short-term immune changes (serum 
      concentrations in response to cardiopulmonary exercise test) of brain-derived 
      neurotrophic factor (BDNF), nerve growth factor (NGF), interleukin-6, and the 
      soluble receptor of IL-6 (sIL-6R) were determined at the beginning and end of 3 
      weeks of training intervention. Subjects performed daily 30 min training at 60 % 
      of their VO2peak. SF-36 total (p = 0.031), physical (p = 0.004), and mental 
      health (p = 0.057) scores show time effects within both groups. Between-group 
      effects were shown for FSMC total (p = 0.040) and motor function score (p = 
      0.041). MFIS physical fatigue showed time effects (p = 0.008) for both groups. 
      Linear regression models showed relationships between short-term immune responses 
      and cardiorespiratory fitness with HR-QoL and fatigue after the intervention. 
      This study indicates beneficial effects of endurance training independent of the 
      training setting. Short-term immune adaptations and cardiorespiratory fitness 
      have the potential to influence HR-QoL and fatigue in persons with MS. The 
      specific immune responses of immersion to exercise need further clarification.
FAU - Bansi, J
AU  - Bansi J
AD  - Kliniken-Valens, Department of Sports Therapy, Rehabilitationsklinik Valens, 
      7317, Valens, Switzerland, jens.bansi@kliniken-valens.ch.
FAU - Bloch, W
AU  - Bloch W
FAU - Gamper, U
AU  - Gamper U
FAU - Riedel, S
AU  - Riedel S
FAU - Kesselring, J
AU  - Kesselring J
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20130914
PL  - Germany
TA  - J Neurol
JT  - Journal of neurology
JID - 0423161
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/blood/immunology
MH  - Exercise Therapy/*methods
MH  - Fatigue/*etiology/rehabilitation
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/complications/*immunology/*rehabilitation
MH  - Nerve Growth Factor/blood/immunology
MH  - Physical Endurance
MH  - *Physical Fitness
MH  - Quality of Life
EDAT- 2013/09/17 06:00
MHDA- 2014/08/07 06:00
CRDT- 2013/09/17 06:00
PHST- 2013/04/24 00:00 [received]
PHST- 2013/08/23 00:00 [accepted]
PHST- 2013/08/22 00:00 [revised]
PHST- 2013/09/17 06:00 [entrez]
PHST- 2013/09/17 06:00 [pubmed]
PHST- 2014/08/07 06:00 [medline]
AID - 10.1007/s00415-013-7091-z [doi]
PST - ppublish
SO  - J Neurol. 2013 Dec;260(12):2993-3001. doi: 10.1007/s00415-013-7091-z. Epub 2013 
      Sep 14.