PMID- 24036912
OWN - NLM
STAT- MEDLINE
DCOM- 20141112
LR  - 20211021
IS  - 1414-431X (Electronic)
IS  - 0100-879X (Print)
IS  - 0100-879X (Linking)
VI  - 46
IP  - 9
DP  - 2013 Sep
TI  - Diastolic function is associated with quality of life and exercise capacity in 
      stable heart failure patients with reduced ejection fraction.
PG  - 803-8
LID - S0100-879X2013005032902 [pii]
LID - 10.1590/1414-431X20132902 [doi]
AB  - Exercise capacity and quality of life (QOL) are important outcome predictors in 
      patients with systolic heart failure (HF), independent of left ventricular (LV) 
      ejection fraction (LVEF). LV diastolic function has been shown to be a better 
      predictor of aerobic exercise capacity in patients with systolic dysfunction and 
      a New York Heart Association (NYHA) classification >/= II. We hypothesized that the 
      currently used index of diastolic function E/e' is associated with exercise 
      capacity and QOL, even in optimally treated HF patients with reduced LVEF. This 
      prospective study included 44 consecutive patients aged 55 +/- 11 years (27 men and 
      17 women), with LVEF<0.50 and NYHA functional class I-III, receiving optimal 
      pharmacological treatment and in a stable clinical condition, as shown by the 
      absence of dyspnea exacerbation for at least 3 months. All patients had 
      conventional transthoracic echocardiography and answered the Minnesota Living 
      with HF Questionnaire, followed by the 6-min walk test (6MWT). In a multivariable 
      model with 6MWT as the dependent variable, age and E/e' explained 27% of the 
      walked distance in 6MWT (P=0.002; multivariate regression analysis). No 
      association was found between walk distance and LVEF or mitral annulus systolic 
      velocity. Only normalized left atrium volume, a sensitive index of diastolic 
      function, was associated with decreased QOL. Despite the small number of patients 
      included, this study offers evidence that diastolic function is associated with 
      physical capacity and QOL and should be considered along with ejection fraction 
      in patients with compensated systolic HF.
FAU - Bussoni, M F
AU  - Bussoni MF
AD  - Universidade Estadual Paulista, Departamento de Clinica Medica, Faculdade de 
      Medicina de Botucatu, BotucatuSP, Brasil.
FAU - Guirado, G N
AU  - Guirado GN
FAU - Roscani, M G
AU  - Roscani MG
FAU - Polegato, B F
AU  - Polegato BF
FAU - Matsubara, L S
AU  - Matsubara LS
FAU - Bazan, S G Z
AU  - Bazan SG
FAU - Matsubara, B B
AU  - Matsubara BB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130830
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de 
      pesquisas medicas e biologicas
JID - 8112917
SB  - IM
MH  - Adult
MH  - Aged
MH  - Diastole/*physiology
MH  - Echocardiography
MH  - Exercise Test/methods
MH  - Exercise Tolerance/*physiology
MH  - Female
MH  - Heart Failure/classification/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prospective Studies
MH  - Quality of Life/*psychology
MH  - Stroke Volume/*physiology
MH  - Surveys and Questionnaires
MH  - Walking/*physiology
PMC - PMC3854427
EDAT- 2013/09/17 06:00
MHDA- 2014/11/13 06:00
PMCR- 2013/08/30
CRDT- 2013/09/17 06:00
PHST- 2012/12/23 00:00 [received]
PHST- 2013/06/21 00:00 [accepted]
PHST- 2013/09/17 06:00 [entrez]
PHST- 2013/09/17 06:00 [pubmed]
PHST- 2014/11/13 06:00 [medline]
PHST- 2013/08/30 00:00 [pmc-release]
AID - S0100-879X2013005032902 [pii]
AID - 10.1590/1414-431X20132902 [doi]
PST - ppublish
SO  - Braz J Med Biol Res. 2013 Sep;46(9):803-8. doi: 10.1590/1414-431X20132902. Epub 
      2013 Aug 30.