PMID- 24038878
OWN - NLM
STAT- MEDLINE
DCOM- 20140617
LR  - 20221207
IS  - 1520-7560 (Electronic)
IS  - 1520-7552 (Linking)
VI  - 30
IP  - 1
DP  - 2014 Jan
TI  - Early postnatal growth in children with HLA-conferred susceptibility to type 1 
      diabetes.
PG  - 60-8
LID - 10.1002/dmrr.2449 [doi]
AB  - AIMS/HYPOTHESIS: An association between increased length/height and weight gain 
      and risk of type 1 diabetes (T1D) has been reported in children. We set out to 
      investigate the potential contribution of T1D human leukocyte antigen (HLA) risk 
      genotypes to this association in two countries with a contrasting disease 
      incidence. METHODS: In Estonia and Finland, length and weight were monitored up 
      to the age of 24 months in 688 subjects. According to their HLA genotypes, the 
      children were divided into four groups, those with very high, high or moderate 
      risk for T1D, as well as a neutral/control group. Relative length and weight 
      (SDS) were assessed and compared at 3, 6, 12, 18 and 24 months using World Health 
      Organization (WHO) growth curves. RESULTS: The mean relative length at the age of 
      24 months was lower in the group with the very high risk HLA genotype compared to 
      the controls (p < 0.05). The mean relative weight differed between those two 
      groups at the age of 12, 18 and 24 months (p < 0.05). When Estonian and Finnish 
      cohorts were analyzed separately, the relative length showed similar but 
      non-significant trends in both countries, while in Estonia the changes in weight 
      at some time points still remained significant (p < 0.05). CONCLUSIONS: Children 
      with the highest HLA-conferred risk for T1D gained less weight and length during 
      the first 24 months of life, and this feature was more pronounced in the Estonian 
      children.
CI  - Copyright (c) 2013 John Wiley & Sons, Ltd.
FAU - Peet, A
AU  - Peet A
AD  - Department of Paediatrics, University of Tartu, Tartu, Estonia; Tartu University 
      Hospital, Tartu, Estonia.
FAU - Hamalainen, A-M
AU  - Hamalainen AM
FAU - Kool, P
AU  - Kool P
FAU - Ilonen, J
AU  - Ilonen J
FAU - Knip, M
AU  - Knip M
FAU - Tillmann, V
AU  - Tillmann V
CN  - DIABIMMUNE Study Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Diabetes Metab Res Rev
JT  - Diabetes/metabolism research and reviews
JID - 100883450
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Body Height
MH  - Body Weight
MH  - Child, Preschool
MH  - Diabetes Mellitus, Type 1/*genetics
MH  - Disease Susceptibility/immunology
MH  - Estonia
MH  - Female
MH  - Finland
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Growth and Development/*genetics/immunology
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Infant
MH  - Insulin Resistance/genetics
MH  - Male
MH  - Sex Characteristics
MH  - White People
OTO - NOTNLM
OT  - HLA-DQ
OT  - environment
OT  - insulin resistance
OT  - linear growth
OT  - type 1 diabetes mellitus
OT  - weight gain
EDAT- 2013/09/17 06:00
MHDA- 2014/06/18 06:00
CRDT- 2013/09/17 06:00
PHST- 2013/02/10 00:00 [received]
PHST- 2013/08/12 00:00 [revised]
PHST- 2013/08/19 00:00 [accepted]
PHST- 2013/09/17 06:00 [entrez]
PHST- 2013/09/17 06:00 [pubmed]
PHST- 2014/06/18 06:00 [medline]
AID - 10.1002/dmrr.2449 [doi]
PST - ppublish
SO  - Diabetes Metab Res Rev. 2014 Jan;30(1):60-8. doi: 10.1002/dmrr.2449.