PMID- 24040157
OWN - NLM
STAT- MEDLINE
DCOM- 20140615
LR  - 20211025
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 9
DP  - 2013
TI  - Radioactive (1)(2)(5)I seed inhibits the cell growth, migration, and invasion of 
      nasopharyngeal carcinoma by triggering DNA damage and inactivating VEGF-A/ERK 
      signaling.
PG  - e74038
LID - 10.1371/journal.pone.0074038 [doi]
LID - e74038
AB  - Although radiotherapy technology has progressed rapidly in the past decade, the 
      inefficiency of radiation and cancer cell resistance mean that the 5-year 
      survival rate of patients with nasopharyngeal carcinoma (NPC) is low. Radioactive 
      (125)I seed implantation has received increasing attention as a clinical 
      treatment for cancers. Vascular endothelial growth factor-A (VEGF-A) is one of 
      the most important members of the VEGF family and plays an important role in cell 
      migration through the extracellular-signal-regulated kinase (ERK) pathway. Here 
      we show that radioactive (125)I seeds more effectively inhibit NPC cell growth 
      through DNA damage and subsequent induction of apoptosis, compared with X-ray 
      irradiation. Moreover, cell migration was effectively inhibited by (125)I seed 
      irradiation through VEGF-A/ERK inactivation. VEGF-A pretreatment significantly 
      blocked (125)I seed irradiation-induced inhibition of cell migration by 
      recovering the levels of phosphorylated ERK (p-ERK) protein. Interestingly, in 
      vivo study results confirmed that (125)I seed irradiation was more effective in 
      inhibiting tumor growth than X-ray irradiation. Taken together, these results 
      suggest that radioactive (125)I seeds exert novel anticancer activity by 
      triggering DNA damage and inactivating VEGF-A/ERK signaling. Our finding provides 
      evidence for the efficacy of (125)I seeds for treating NPC patients, especially 
      those with local recurrence.
FAU - Tian, Yunhong
AU  - Tian Y
AD  - Cancer Research Institute, Southern Medical University, Guangzhou, Guangdong 
      Province, People's Republic of China ; Department of Oncology, Armed Police 
      Hospital of Guangdong Province, Guangzhou, Guangdong Province, People's Republic 
      of China.
FAU - Xie, Qiang
AU  - Xie Q
FAU - Tian, Yunming
AU  - Tian Y
FAU - Liu, Ying
AU  - Liu Y
FAU - Huang, Zuoping
AU  - Huang Z
FAU - Fan, Cundong
AU  - Fan C
FAU - Hou, Bing
AU  - Hou B
FAU - Sun, Dan
AU  - Sun D
FAU - Yao, Kaitai
AU  - Yao K
FAU - Chen, Tianfeng
AU  - Chen T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130910
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Iodine Radioisotopes)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
SB  - IM
MH  - Animals
MH  - Apoptosis/radiation effects
MH  - Carcinoma
MH  - Cell Cycle Checkpoints/radiation effects
MH  - Cell Line, Tumor
MH  - Cell Movement/radiation effects
MH  - Cell Proliferation/radiation effects
MH  - DNA Damage/*radiation effects
MH  - Disease Models, Animal
MH  - Extracellular Signal-Regulated MAP Kinases/*metabolism
MH  - Female
MH  - Humans
MH  - Iodine Radioisotopes/*administration & dosage
MH  - Mice
MH  - Nasopharyngeal Carcinoma
MH  - Nasopharyngeal Neoplasms/*genetics/*metabolism/pathology/radiotherapy
MH  - Neoplasm Invasiveness
MH  - Reactive Oxygen Species/metabolism
MH  - Signal Transduction/*radiation effects
MH  - Tumor Burden/radiation effects
MH  - Vascular Endothelial Growth Factor A/*metabolism
MH  - X-Rays
MH  - Xenograft Model Antitumor Assays
PMC - PMC3769370
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/09/17 06:00
MHDA- 2014/06/16 06:00
PMCR- 2013/09/10
CRDT- 2013/09/17 06:00
PHST- 2013/05/02 00:00 [received]
PHST- 2013/07/25 00:00 [accepted]
PHST- 2013/09/17 06:00 [entrez]
PHST- 2013/09/17 06:00 [pubmed]
PHST- 2014/06/16 06:00 [medline]
PHST- 2013/09/10 00:00 [pmc-release]
AID - PONE-D-13-17896 [pii]
AID - 10.1371/journal.pone.0074038 [doi]
PST - epublish
SO  - PLoS One. 2013 Sep 10;8(9):e74038. doi: 10.1371/journal.pone.0074038. eCollection 
      2013.