PMID- 24040459
OWN - NLM
STAT- MEDLINE
DCOM- 20140418
LR  - 20211021
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 6
IP  - 9
DP  - 2013
TI  - Primary sacral non-germinal center type diffuse large B-cell lymphoma with MYC 
      translocation: a case report and a review of the literature.
PG  - 1919-28
AB  - An 85-year-old man presented with pain and numbness in the left buttock, and 
      physical examination revealed an approximately 7 cm mass extending from the first 
      to the third sacral vertebrae; biopsy of the mass led to the diagnosis of 
      CD10-negative, BCL6-weakly positive, MUM1-positive, non-germinal center (non-GC) 
      type diffuse large B-cell lymphoma (DLBCL). Furthermore, serological testing 
      showed negative results for Epstein-Barr virus (EBV) infection, and fluorescence 
      in situ hybridization (FISH) revealed a MYC translocation. Radiographs showed no 
      remarkable osteolytic bone destruction, and the patient was staged with Stage 
      IAE. After 8 cycles of rituximab therapy and 6 cycles of CHOP therapy, complete 
      remission has been maintained until now, approximately 1 year after the 
      treatment. Primary sacral lymphoma is very rare, with only 6 reported cases, 
      including the present one. A review of the reported cases revealed that the 
      disease predominantly affects elderly men, is usually non-GC-type DLBCL and stage 
      IAE, measures approximately 2-7 cm in diameter in general, and does not show 
      early recurrence after chemotherapy or chemoradiotherapy. There is no report in 
      the literature yet of primary sacral DLBCL with MYC translocation, and this is 
      the first case report. On the other hand, 35 cases of CD10-negative DLBCL with 
      MYC translocation, including the present one, have been reported, and a review of 
      the reported cases showed that the disease predominantly affects Asians, 
      middle-aged or elderly men, shows positivity for either BCL6 or MUM1 and 
      negativity for EBV, and has a high international prognostic index and poor 
      prognosis.
FAU - Shimada, Asami
AU  - Shimada A
AD  - Department of Hematology, Juntendo University Urayasu Hospital Urayasu, Japan.
FAU - Sugimoto, Kei-Ji
AU  - Sugimoto KJ
FAU - Wakabayashi, Mutsumi
AU  - Wakabayashi M
FAU - Imai, Hidenori
AU  - Imai H
FAU - Sekiguchi, Yasunobu
AU  - Sekiguchi Y
FAU - Nakamura, Noriko
AU  - Nakamura N
FAU - Sawada, Tomohiro
AU  - Sawada T
FAU - Ota, Yasunori
AU  - Ota Y
FAU - Komatsu, Norio
AU  - Komatsu N
FAU - Noguchi, Masaaki
AU  - Noguchi M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20130815
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (MYC protein, human)
RN  - 0 (Proto-Oncogene Proteins c-myc)
SB  - IM
MH  - Aged, 80 and over
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Biomarkers, Tumor/analysis/*genetics
MH  - Biopsy
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, Large B-Cell, Diffuse/chemistry/drug therapy/*genetics/pathology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Phenotype
MH  - Positron-Emission Tomography
MH  - Proto-Oncogene Proteins c-myc/*genetics
MH  - Remission Induction
MH  - *Sacrum/pathology
MH  - Spinal Neoplasms/chemistry/drug therapy/*genetics/pathology
MH  - Tomography, X-Ray Computed
MH  - *Translocation, Genetic
MH  - Treatment Outcome
PMC - PMC3759501
OTO - NOTNLM
OT  - CD10-negative
OT  - MYC
OT  - Primary sacral lymphoma
OT  - non-germinal center DLBCL
OT  - paraffin-embedded tissue section-fluorescence in-situ hybridization
EDAT- 2013/09/17 06:00
MHDA- 2014/04/20 06:00
PMCR- 2013/08/15
CRDT- 2013/09/17 06:00
PHST- 2013/07/16 00:00 [received]
PHST- 2013/07/30 00:00 [accepted]
PHST- 2013/09/17 06:00 [entrez]
PHST- 2013/09/17 06:00 [pubmed]
PHST- 2014/04/20 06:00 [medline]
PHST- 2013/08/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2013 Aug 15;6(9):1919-28. eCollection 2013.