PMID- 24040464
OWN - NLM
STAT- MEDLINE
DCOM- 20140418
LR  - 20211021
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 6
IP  - 9
DP  - 2013
TI  - Sporadic hemangioblastoma of the kidney with PAX2 and focal CD10 expression: 
      report of a case.
PG  - 1953-6
AB  - In this study, we presented an additional case of renal hemangioblastoma, which 
      demonstrates PAX2 and focal CD10 expression. Histologically, the tumor consisted 
      of sheets of oval or polygonal cells and a prominent vascular network. The tumor 
      cells varied in size, and possessed pale or eosinophilic cytoplasm that sometimes 
      contained sharply delineated fine vacuoles. The tumor cell nuclei with 
      inconspicuous nucleoli showed moderate nuclear atypia and pleomorphism. Focal 
      areas of stromal hyalinization and sclerosis were detected. On account of its 
      strong or moderate immunoreactivity for the a-inhibin, S100, NSE, and EGFR, the 
      diagnosis of renal hemangioblastoma was established. For further evidence of VHL 
      deficiency, the tumor was subjected to VHL sequence analysis of all three exons 
      and fluorescence in situ hybridization (FISH) detection for chromosome 3p 
      deletion. None of the VHL gene mutations and chromosome 3p deletion was detected 
      in the tumor. Because of several shared morphological and immunophenotypic 
      features, renal hemangioblastoma may be underrecognized and should be included in 
      the differential diagnosis of primary renal tumors, in particular clear cell 
      renal cell carcinoma. The unexpected positive staining of PAX2 and CD10 in renal 
      hemangioblastoma should be particular concerned. Using a combination of 
      immunoprofile may be helpful to the differential diagnosis of these renal tumors.
FAU - Jiang, Jin-Gui
AU  - Jiang JG
AD  - Department of Pathology, Jinhu County People's Hospital Jiangsu Province, China.
FAU - Rao, Qiu
AU  - Rao Q
FAU - Xia, Qiu-Yuan
AU  - Xia QY
FAU - Tu, Pin
AU  - Tu P
FAU - Lu, Zhen-Feng
AU  - Lu ZF
FAU - Shen, Qin
AU  - Shen Q
FAU - Zhang, Ru-Song
AU  - Zhang RS
FAU - Yu, Bo
AU  - Yu B
FAU - Zhou, Xiao-Jun
AU  - Zhou XJ
FAU - Shi, Shan-Shan
AU  - Shi SS
FAU - Shi, Qun-Li
AU  - Shi QL
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130815
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (PAX2 Transcription Factor)
RN  - 0 (PAX2 protein, human)
RN  - EC 2.3.2.27 (Von Hippel-Lindau Tumor Suppressor Protein)
RN  - EC 3.4.24.11 (Neprilysin)
RN  - EC 6.3.2.- (VHL protein, human)
SB  - IM
MH  - Biomarkers, Tumor/*analysis/genetics
MH  - Biopsy
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Pair 3
MH  - Diagnosis, Differential
MH  - Female
MH  - Hemangioblastoma/*chemistry/genetics/pathology/surgery
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Kidney Neoplasms/*chemistry/genetics/pathology/surgery
MH  - Middle Aged
MH  - Mutation
MH  - Nephrectomy
MH  - Neprilysin/*analysis
MH  - PAX2 Transcription Factor/*analysis
MH  - Predictive Value of Tests
MH  - Treatment Outcome
MH  - Von Hippel-Lindau Tumor Suppressor Protein/genetics
PMC - PMC3759506
OTO - NOTNLM
OT  - CD10
OT  - Kidney
OT  - PAX2
OT  - differential diagnosis
OT  - fluorescence in situ ridization (FISH)
OT  - hemangioblastoma
OT  - molecular genetics
OT  - von-Hippel-Lindau (VHL)
EDAT- 2013/09/17 06:00
MHDA- 2014/04/20 06:00
PMCR- 2013/08/15
CRDT- 2013/09/17 06:00
PHST- 2013/06/19 00:00 [received]
PHST- 2013/07/12 00:00 [accepted]
PHST- 2013/09/17 06:00 [entrez]
PHST- 2013/09/17 06:00 [pubmed]
PHST- 2014/04/20 06:00 [medline]
PHST- 2013/08/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2013 Aug 15;6(9):1953-6. eCollection 2013.