PMID- 2404463
OWN - NLM
STAT- MEDLINE
DCOM- 19900209
LR  - 20220311
IS  - 0003-987X (Print)
IS  - 0003-987X (Linking)
VI  - 126
IP  - 1
DP  - 1990 Jan
TI  - Histopathologic comparison of the subsets of lupus erythematosus.
PG  - 52-5
AB  - A recent study by Bangert et al suggests that there are quantitative histologic 
      differences that distinguish discoid lupus erythematosus (DLE) and subacute 
      cutaneous lupus erythematosus (SCLE). Utilizing criteria proposed by these 
      authors, we examined 77 biopsy specimens from 63 patients with various forms of 
      lupus erythematosus, but we were unable to predict the correct clinical subset. 
      Using the clinical diagnosis of DLE as a positive reference standard, the 
      sensitivity and specificity for the overall pathologic diagnosis of DLE were 55% 
      and 42%, respectively. Statistically significant histologic factors favoring the 
      diagnosis of DLE over SCLE in the present study were pilosebaceous atrophy, 
      hyperkeratosis, parakeratosis, basement membrane thickening around the follicles, 
      subepidermal edema, and vascular ectasia. These histologic variables were entered 
      into a forward stepwise multivariate regression analysis to determine distinct 
      predictors of DLE vs SCLE. This analysis showed that pilosebaceous atrophy was 
      the only distinct significant predictor of DLE vs SCLE. These results suggest 
      that the histologic differentiation of clinically defined DLE and SCLE cannot be 
      established from the histologic features examined.
FAU - Jerdan, M S
AU  - Jerdan MS
AD  - Department of Dermatology, Johns Hopkins Medical Institutions, Baltimore, Md.
FAU - Hood, A F
AU  - Hood AF
FAU - Moore, G W
AU  - Moore GW
FAU - Callen, J P
AU  - Callen JP
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Arch Dermatol
JT  - Archives of dermatology
JID - 0372433
SB  - IM
CIN - Arch Dermatol. 1990 Dec;126(12):1651. PMID: 2256694
MH  - Atrophy
MH  - Basement Membrane/pathology
MH  - Epidermis/pathology
MH  - Hair/pathology
MH  - Humans
MH  - Inflammation
MH  - Keratosis/pathology
MH  - Lupus Erythematosus, Cutaneous/classification/*pathology
MH  - Lupus Erythematosus, Discoid/classification/*pathology
MH  - Multivariate Analysis
MH  - Probability
MH  - Regression Analysis
MH  - Sensitivity and Specificity
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
PST - ppublish
SO  - Arch Dermatol. 1990 Jan;126(1):52-5.