PMID- 24045117
OWN - NLM
STAT- MEDLINE
DCOM- 20140610
LR  - 20211021
IS  - 1532-3064 (Electronic)
IS  - 0954-6111 (Print)
IS  - 0954-6111 (Linking)
VI  - 107
IP  - 11
DP  - 2013 Nov
TI  - Nitrogen dioxide and allergic sensitization in the 2005-2006 National Health and 
      Nutrition Examination Survey.
PG  - 1763-72
LID - S0954-6111(13)00311-9 [pii]
LID - 10.1016/j.rmed.2013.08.010 [doi]
AB  - BACKGROUND: Allergic sensitization is a risk factor for asthma and allergic 
      diseases. The relationship between ambient air pollution and allergic 
      sensitization is unclear. OBJECTIVE: To investigate the relationship between 
      ambient air pollution and allergic sensitization in a nationally representative 
      sample of the US population. METHODS: We linked annual average concentrations of 
      nitrogen dioxide (NO2), particulate matter </=10 mum (PM10), particulate matter 
      </=2.5 mum (PM2.5), and summer concentrations of ozone (O3), to allergen-specific 
      immunoglobulin E (IgE) data for participants in the 2005-2006 National Health and 
      Nutrition Examination Survey (NHANES). In addition to the monitor-based air 
      pollution estimates, we used the Community Multiscale Air Quality (CMAQ) model to 
      increase the representation of rural participants in our sample. Logistic 
      regression with population-based sampling weights was used to calculate adjusted 
      prevalence odds ratios per 10 ppb increase in O3 and NO2, per 10 mug/m(3) increase 
      in PM10, and per 5 mug/m(3) increase in PM2.5 adjusting for race, gender, age, 
      socioeconomic status, smoking, and urban/rural status. RESULTS: Using CMAQ data, 
      increased levels of NO2 were associated with positive IgE to any (OR 1.15, 95% CI 
      1.04, 1.27), inhalant (OR 1.17, 95% CI 1.02, 1.33), and indoor (OR 1.16, 95% CI 
      1.03, 1.31) allergens. Higher PM2.5 levels were associated with positivity to 
      indoor allergen-specific IgE (OR 1.24, 95% CI 1.13, 1.36). Effect estimates were 
      similar using monitored data. CONCLUSIONS: Increased ambient NO2 was consistently 
      associated with increased prevalence of allergic sensitization.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Weir, Charles H
AU  - Weir CH
AD  - Department of Environmental Sciences and Engineering, Gillings School of Global 
      Public Health, University of North Carolina, Chapel Hill, NC, USA.
FAU - Yeatts, Karin B
AU  - Yeatts KB
FAU - Sarnat, Jeremy A
AU  - Sarnat JA
FAU - Vizuete, William
AU  - Vizuete W
FAU - Salo, Paivi M
AU  - Salo PM
FAU - Jaramillo, Renee
AU  - Jaramillo R
FAU - Cohn, Richard D
AU  - Cohn RD
FAU - Chu, Haitao
AU  - Chu H
FAU - Zeldin, Darryl C
AU  - Zeldin DC
FAU - London, Stephanie J
AU  - London SJ
LA  - eng
GR  - ZIA ES025041-16/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20130828
PL  - England
TA  - Respir Med
JT  - Respiratory medicine
JID - 8908438
RN  - 0 (Particulate Matter)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - S7G510RUBH (Nitrogen Dioxide)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Air Pollution/*adverse effects/analysis
MH  - Child
MH  - Environmental Exposure/adverse effects/analysis/statistics & numerical data
MH  - Environmental Monitoring/methods
MH  - Female
MH  - Humans
MH  - Hypersensitivity/epidemiology/*etiology/immunology
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Middle Aged
MH  - Nitrogen Dioxide/analysis/*immunology
MH  - Nutrition Surveys
MH  - Particulate Matter/analysis/*immunology
MH  - Prevalence
MH  - United States/epidemiology
MH  - Young Adult
PMC - PMC4071349
MID - NIHMS585225
OTO - NOTNLM
OT  - Air pollution
OT  - Allergic
OT  - Epidemiology
OT  - IgE
OT  - NHANES
OT  - Sensitization
EDAT- 2013/09/21 06:00
MHDA- 2014/06/11 06:00
PMCR- 2014/06/26
CRDT- 2013/09/19 06:00
PHST- 2013/05/21 00:00 [received]
PHST- 2013/07/30 00:00 [revised]
PHST- 2013/08/14 00:00 [accepted]
PHST- 2013/09/19 06:00 [entrez]
PHST- 2013/09/21 06:00 [pubmed]
PHST- 2014/06/11 06:00 [medline]
PHST- 2014/06/26 00:00 [pmc-release]
AID - S0954-6111(13)00311-9 [pii]
AID - 10.1016/j.rmed.2013.08.010 [doi]
PST - ppublish
SO  - Respir Med. 2013 Nov;107(11):1763-72. doi: 10.1016/j.rmed.2013.08.010. Epub 2013 
      Aug 28.