PMID- 24045217
OWN - NLM
STAT- MEDLINE
DCOM- 20140624
LR  - 20161125
IS  - 1883-0498 (Electronic)
IS  - 0023-2513 (Linking)
VI  - 59
IP  - 3
DP  - 2013 Jun 17
TI  - Myocardial impairment detected by late gadolinium enhancement in hypertrophic 
      cardiomyopathy: comparison with 99mTc-MIBI/tetrofosmin and 123I-BMIPP SPECT.
PG  - E81-92
AB  - PURPOSE: Myocardial fibrosis is considered to be an important factor in 
      myocardial dysfunction and sudden cardiac death in hypertrophic cardiomyopathy 
      (HCM). The purpose of this study was to compare myocardial fibrosis detected by 
      late gadolinium enhancement (LGE) on cardiac MRI with myocardial perfusion and 
      fatty acid metabolism assessed by single photon emission computed tomography in 
      HCM. MATERIALS AND METHODS: We retrospectively evaluated 20 consecutive HCM 
      patients (female, 7; mean age, 53.4 years) who underwent LGE, technetium-99m 
      methoxyisobutylisonitrile/tetrofosmin (99mTc-MIBI/tetrofosmin), and iodine-123 
      beta-methyl-iodophenylpentadecanoic acid (123I-BMIPP) imaging. We calculated the 
      myocardium-to-lumen signal ratio (M/L) for LGE in 17 segments based on the 
      American Heart Association statement. Scoring of 99mTc-MIBI/tetrofosmin (PI) and 
      123I-BMIPP (BM) was performed for each segment using a 5-point scale (0, normal; 
      4, highly decreased). RESULTS: Nineteen of 20 patients (95%) and 153 of 340 
      segments (45%) showed LGE. M/Ls were 0.42+/-0.16, 0.55+/-0.17, and 0.65+/-0.24 in 
      PI0/BM0, PI0/BM1-4 and PI1-4/BM1-4, respectively. All M/Ls were significantly 
      higher than that of a normal control (0.34+/-0.14) (p<0.001). CONCLUSIONS: 
      Myocardial fibrosis in HCM can occur despite normal perfusion and fatty acid 
      metabolism, and is more strongly associated with disorders of fatty acid 
      metabolism than with perfusion abnormalities. M/L may be a useful indicator of 
      disease severity.
FAU - Hashimura, Hiromi
AU  - Hashimura H
AD  - Department of Radiology, National Cerebral and Cardiovascular Center 5-7-1 
      Fujishiro-dai, Suita, 565-8565 Osaka, Japan.
FAU - Kiso, Keisuke
AU  - Kiso K
FAU - Yamada, Naoaki
AU  - Yamada N
FAU - Kono, Atsushi
AU  - Kono A
FAU - Morita, Yoshiaki
AU  - Morita Y
FAU - Fukushima, Kazuto
AU  - Fukushima K
FAU - Higashi, Masahiro
AU  - Higashi M
FAU - Noguchi, Teruo
AU  - Noguchi T
FAU - Ishibashi-Ueda, Hatsue
AU  - Ishibashi-Ueda H
FAU - Naito, Hiroaki
AU  - Naito H
FAU - Sugimura, Kazuro
AU  - Sugimura K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20130617
PL  - Japan
TA  - Kobe J Med Sci
JT  - The Kobe journal of medical sciences
JID - 0413531
RN  - 0 (Fatty Acids)
RN  - 0 (Iodine Radioisotopes)
RN  - 0 (Iodobenzenes)
RN  - 0 (Organophosphorus Compounds)
RN  - 0 (Organotechnetium Compounds)
RN  - 0 (Radiopharmaceuticals)
RN  - 0J7USQ749M (iodofiltic acid)
RN  - 42FOP1YX93 (technetium tc-99m tetrofosmin)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiomyopathy, Hypertrophic/*diagnostic imaging/metabolism/pathology
MH  - *Fatty Acids/metabolism
MH  - Female
MH  - Fibrosis
MH  - *Gadolinium DTPA
MH  - Humans
MH  - *Iodine Radioisotopes
MH  - *Iodobenzenes
MH  - Male
MH  - Middle Aged
MH  - Myocardium/pathology
MH  - *Organophosphorus Compounds
MH  - *Organotechnetium Compounds
MH  - *Radiopharmaceuticals
MH  - Retrospective Studies
MH  - Tomography, Emission-Computed, Single-Photon/*methods
EDAT- 2013/09/21 06:00
MHDA- 2014/06/25 06:00
CRDT- 2013/09/19 06:00
PHST- 2013/09/19 06:00 [entrez]
PHST- 2013/09/21 06:00 [pubmed]
PHST- 2014/06/25 06:00 [medline]
PST - epublish
SO  - Kobe J Med Sci. 2013 Jun 17;59(3):E81-92.