PMID- 24045789
OWN - NLM
STAT- MEDLINE
DCOM- 20140721
LR  - 20140731
IS  - 1476-5640 (Electronic)
IS  - 0954-3007 (Linking)
VI  - 67
IP  - 12
DP  - 2013 Dec
TI  - Effect of a carbohydrate-containing late-evening snack on energy metabolism and 
      fasting substrate utilization in adults with acute-on-chronic liver failure due 
      to Hepatitis B.
PG  - 1251-6
LID - 10.1038/ejcn.2013.163 [doi]
AB  - BACKGROUND/OBJECTIVES: This study investigates the effects of a carbohydrate 
      (CHO; lotus-root starch) predominant, late-evening snack (LES), containing 
      200 kcal (50 g CHO) on fasting resting energy expenditure (REE) and nutrient 
      oxidation in hospitalized adults with acute-on-chronic liver failure (ACLF). 
      SUBJECTS/METHODS: Adults with ACLF were randomized to receive daily LES 
      (treatment; n=35) or standard care (n=35; non-supplemented control) for 14 days. 
      REE and respiratory quotient (RQ) were measured by indirect calorimetry, nutrient 
      oxidation (CHO, protein and fat), intake and biochemical parameters were measured 
      in both groups at baseline and after 14 days using validated techniques. Disease 
      severity was measured using the model for end-stage liver disease (MELD). 
      RESULTS: No significant differences in macronutrient intake, anthropometric, 
      demographic characteristics or MELD scores were observed between groups at 
      baseline (P>0.05). Fasting RQ was significantly higher in the LES supplemented 
      verses the control group after 2 weeks (P=0.02). CHO oxidation was significantly 
      higher (P=0.001) and fat oxidation (P=0.02) was lower in the LES-supplemented 
      group when compared with controls after 2 weeks. Fasting RQ and REE in the 
      LES-supplemented group increased significantly (0.83 verses 0.88; 
      P=0.007/1301+/-409 vs 1687+/-718 kcal/day; P=0.02) in patients with MELD scores </=30 
      when compared with patients with MELD scores >30 (0.82 verses 0.84; P=0.27/ 
      1361+/-405 vs 1437+/-429 kcal/day; P=0.67) after supplementation. CONCLUSIONS: A 
      carbohydrate-predominant LES is associated with increases in fasting carbohydrate 
      oxidation, REE and reductions in fat oxidation in adults with ACLF. Therapeutic 
      strategies utilizing LES may promote improved nutritional status in adults with 
      ACLF.
FAU - Hou, W
AU  - Hou W
AD  - Department of Hepatology, Beijing You An Hospital, Capital Medical University, 
      Beijing, China.
FAU - Li, J
AU  - Li J
FAU - Lu, J
AU  - Lu J
FAU - Wang, J H
AU  - Wang JH
FAU - Zhang, F Y
AU  - Zhang FY
FAU - Yu, H W
AU  - Yu HW
FAU - Zhang, J
AU  - Zhang J
FAU - Yao, Q W
AU  - Yao QW
FAU - Wu, J
AU  - Wu J
FAU - Shi, S Y
AU  - Shi SY
FAU - Mager, D R
AU  - Mager DR
FAU - Meng, Q H
AU  - Meng QH
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20130918
PL  - England
TA  - Eur J Clin Nutr
JT  - European journal of clinical nutrition
JID - 8804070
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
SB  - IM
MH  - Adult
MH  - China
MH  - Diet
MH  - Dietary Carbohydrates/*administration & dosage/metabolism
MH  - Dietary Fats/metabolism
MH  - End Stage Liver Disease/*diet therapy/virology
MH  - *Energy Metabolism
MH  - Fasting
MH  - Female
MH  - Hepatitis B/*complications
MH  - Humans
MH  - Liver Failure, Acute/*diet therapy/virology
MH  - Male
MH  - Middle Aged
MH  - Nutrition Therapy
MH  - Oxidation-Reduction
MH  - *Snacks
EDAT- 2013/09/21 06:00
MHDA- 2014/07/22 06:00
CRDT- 2013/09/19 06:00
PHST- 2013/01/11 00:00 [received]
PHST- 2013/07/17 00:00 [revised]
PHST- 2013/08/02 00:00 [accepted]
PHST- 2013/09/19 06:00 [entrez]
PHST- 2013/09/21 06:00 [pubmed]
PHST- 2014/07/22 06:00 [medline]
AID - ejcn2013163 [pii]
AID - 10.1038/ejcn.2013.163 [doi]
PST - ppublish
SO  - Eur J Clin Nutr. 2013 Dec;67(12):1251-6. doi: 10.1038/ejcn.2013.163. Epub 2013 
      Sep 18.