PMID- 24046278
OWN - NLM
STAT- MEDLINE
DCOM- 20140804
LR  - 20141120
IS  - 1096-0929 (Electronic)
IS  - 1096-0929 (Linking)
VI  - 136
IP  - 2
DP  - 2013 Dec
TI  - The atopic dermatitis-like symptoms induced by MC903 were alleviated in JNK1 
      knockout mice.
PG  - 443-9
LID - 10.1093/toxsci/kft215 [doi]
AB  - Atopic dermatitis (AD) is a common allergic disease, imposing large social and 
      economic burdens worldwide. Atopic dermatitis is characterized by eczematous skin 
      lesions and immunoglobulin E (IgE) hypersecretion. We investigated the role of 
      JNK1 on the development of AD in mice. The vitamin D3 analogue MC903, a psoriasis 
      therapeutic drug, was used to induce AD-like symptoms in wild-type (WT) and 
      JNK1-/- mice. The symptoms of AD were less severe in JNK1-/- mice compared with 
      WT mice. JNK1-/- mice showed less ear thickening and infiltration of eosinophils 
      and mast cells in AD-like lesions than did WT mice when treated with MC903. 
      MC903-treated JNK1-/- mice also showed significantly lower level of serum IgE, 
      which was elevated in MC903-treated WT mice. Splenocytes isolated from 
      MC903-treated WT and JNK1-/- mice were stimulated with anti-CD3 and anti-CD28 
      monoclonal antibodies. Splenocytes from JNK1-/- mice produced lower levels of 
      T-helper (Th2) cytokines (interleukin-4 and -13) and transcription factor 
      GATA-binding protein 3, and produced increased levels of the Th1 cytokines 
      interferon-gamma and transcription factor T-box expressed in T cells. Our results 
      indicate that JNK1 plays an important role in the pathogenesis of AD and may be a 
      useful target for therapies to ameliorate AD.
FAU - Choi, Jinhwan
AU  - Choi J
AD  - * WCU Biomodulation Major, Department of Agricultural Biotechnology and Center 
      for Food and Bioconvergence, Seoul National University, Seoul 151-921, Republic 
      of Korea;
FAU - Kim, Jong Rhan
AU  - Kim JR
FAU - Kim, Heejeung
AU  - Kim H
FAU - Kim, Yoon A
AU  - Kim YA
FAU - Lee, Hyong Joo
AU  - Lee HJ
FAU - Kim, Jiyoung
AU  - Kim J
FAU - Lee, Ki Won
AU  - Lee KW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130917
PL  - United States
TA  - Toxicol Sci
JT  - Toxicological sciences : an official journal of the Society of Toxicology
JID - 9805461
RN  - 0 (Cytokines)
RN  - 143NQ3779B (calcipotriene)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 8)
RN  - FXC9231JVH (Calcitriol)
SB  - IM
MH  - Animals
MH  - Calcitriol/*analogs & derivatives/toxicity
MH  - Cytokines/metabolism
MH  - Dermatitis, Atopic/chemically induced/*genetics
MH  - Female
MH  - Immunoglobulin E/blood
MH  - Mice
MH  - Mice, Knockout
MH  - Mitogen-Activated Protein Kinase 8/genetics/*metabolism
MH  - Spleen/metabolism
OTO - NOTNLM
OT  - GATA-3
OT  - IgE
OT  - JNK1
OT  - T-bet.
OT  - atopic dermatitis
OT  - cytokines
EDAT- 2013/09/21 06:00
MHDA- 2014/08/05 06:00
CRDT- 2013/09/19 06:00
PHST- 2013/09/19 06:00 [entrez]
PHST- 2013/09/21 06:00 [pubmed]
PHST- 2014/08/05 06:00 [medline]
AID - kft215 [pii]
AID - 10.1093/toxsci/kft215 [doi]
PST - ppublish
SO  - Toxicol Sci. 2013 Dec;136(2):443-9. doi: 10.1093/toxsci/kft215. Epub 2013 Sep 17.