PMID- 2404636
OWN - NLM
STAT- MEDLINE
DCOM- 19900313
LR  - 20131121
IS  - 0009-7322 (Print)
IS  - 0009-7322 (Linking)
VI  - 81
IP  - 2 Suppl
DP  - 1990 Feb
TI  - Effects of long-term treatment with calcium antagonists on left ventricular 
      diastolic function in stable angina and heart failure.
PG  - III130-8
AB  - The appearance of impaired left ventricular diastolic function in chronic 
      ischemic heart disease often precedes systolic dysfunction. Myocardial ischemia 
      and increased calcium loading have been implicated in the genesis of increased 
      left ventricular stiffness. We have assessed the effects of long-term therapy 
      with different classes of calcium channel-blocking drugs on left ventricular peak 
      filling rate in patients with chronic stable angina and congestive heart failure 
      secondary to ischemic heart disease. Therapeutic effects of nicardipine (30 mg 
      t.i.d.), nisoldipine (10 mg b.i.d.), and verapamil (120 mg t.i.d.) (4 weeks) have 
      been assessed on radionuclide left ventricular diastolic filling parameters in 
      patients with chronic stable angina using placebo-controlled studies. All three 
      drugs significantly improved exercise capacity as compared with placebo. 
      Verapamil produced significant improvements in peak filling rate (p less than 
      0.005), time to peak filling rate (p less than 0.01), and first one-third filling 
      fraction (p less than 0.005), whereas nicardipine only improved peak filling rate 
      (p less than 0.005); neither drug altered the mean ejection fraction (n = 20). 
      Nisoldipine did not significantly alter diastolic filling parameters or ejection 
      fraction (n = 10). Nisoldipine and digoxin were also assessed in congestive heart 
      failure (New York Heart Association [NYHA] classes II and III) associated with 
      ischemic heart disease (n = 26) (open parallel design). Neither produced 
      significant alterations in peak filling rate and ejection fraction after 3 months 
      of therapy.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Lahiri, A
AU  - Lahiri A
AD  - Department of Cardiology, Northwick Park Hospital, Middlesex, England.
FAU - Rodrigues, E A
AU  - Rodrigues EA
FAU - Carboni, G P
AU  - Carboni GP
FAU - Raftery, E B
AU  - Raftery EB
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
RN  - 0 (Calcium Channel Blockers)
RN  - 73K4184T59 (Digoxin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Angina Pectoris/*drug therapy
MH  - Calcium Channel Blockers/*therapeutic use
MH  - Cardiac Output/drug effects
MH  - Digoxin/therapeutic use
MH  - Exercise Test
MH  - Heart Failure/*drug therapy
MH  - Humans
MH  - Middle Aged
MH  - Myocardial Contraction/*drug effects
MH  - Radionuclide Ventriculography
MH  - Randomized Controlled Trials as Topic
MH  - Stroke Volume/drug effects
MH  - Time Factors
EDAT- 1990/02/01 00:00
MHDA- 1990/02/01 00:01
CRDT- 1990/02/01 00:00
PHST- 1990/02/01 00:00 [pubmed]
PHST- 1990/02/01 00:01 [medline]
PHST- 1990/02/01 00:00 [entrez]
PST - ppublish
SO  - Circulation. 1990 Feb;81(2 Suppl):III130-8.