PMID- 24046531
OWN - NLM
STAT- MEDLINE
DCOM- 20140411
LR  - 20211021
IS  - 1449-1907 (Electronic)
IS  - 1449-1907 (Linking)
VI  - 10
IP  - 11
DP  - 2013
TI  - S100A11 is a migration-related protein in laryngeal squamous cell carcinoma.
PG  - 1552-9
LID - 10.7150/ijms.5986 [doi]
AB  - OBJECTIVE: As a member of the S100 proteins family, the involvement of S100A11 
      has been suggested in a wide range of biological processes such as cell growth 
      and motility, cell-cycle progression, transcription, differentiation and smooth 
      muscle cell migration. However, the expression of S100A11 and its exact function 
      in laryngeal squamous cell carcinoma (LSCC) have not been elucidated. METHODS: 
      The protein and mRNA expression levels of S100A11 were analyzed in primary tumors 
      and matched tumor-adjacent tissues of LSCC by western blotting and 
      semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) or 
      quantitative real time PCR (Q-RT-PCR), respectively. Cell proliferation, colony 
      formation, migration and wound-healing assays were performed to assess whether 
      the knockdown of S100A11 by small interfering RNA (siRNA) could influence the 
      biological behavior of human laryngeal carcinoma Hep-2 cells in vitro. RESULTS: 
      We found that both protein and mRNA levels of S100A11 were overexpressed in 
      laryngeal tumor tissues when compared to the corresponding noncancerous tissues. 
      Further, it was demonstrated that the expression of S100A11 could induce 
      migration but not proliferation of Hep-2 cells. Additionally, S100A11 altered a 
      series of intracellular events, including the down-regulation of epidermal growth 
      factor receptor (EGFR), CD44 and MMP2. CONCLUSIONS: These results highlight the 
      significance of S100A11 in LSCC progression and suggest that the dysregulation of 
      S100A11 might contribute to the metastatic progression of LSCC.
FAU - Wang, Chengyu
AU  - Wang C
AD  - 1. Department of Otolaryngology-Head and Neck Surgery, Changzheng Hospital, 
      Second Military Medical University, Shanghai 200003, China;
FAU - Zhang, Zhenwei
AU  - Zhang Z
FAU - Li, Li
AU  - Li L
FAU - Zhang, Jianpeng
AU  - Zhang J
FAU - Wang, Jiasen
AU  - Wang J
FAU - Fan, Jingping
AU  - Fan J
FAU - Jiao, Binghua
AU  - Jiao B
FAU - Zhao, Shuwei
AU  - Zhao S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130906
PL  - Australia
TA  - Int J Med Sci
JT  - International journal of medical sciences
JID - 101213954
RN  - 0 (RNA, Small Interfering)
RN  - 0 (S100 Proteins)
RN  - 146909-89-9 (S100A11 protein, human)
SB  - IM
MH  - Blotting, Western
MH  - Carcinoma, Squamous Cell/genetics/*metabolism
MH  - Cell Line, Tumor
MH  - Cell Movement/genetics/physiology
MH  - Cell Proliferation
MH  - Head and Neck Neoplasms/genetics/*metabolism
MH  - Humans
MH  - Laryngeal Neoplasms/genetics/*metabolism
MH  - RNA, Small Interfering/genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - S100 Proteins/genetics/*metabolism
MH  - Squamous Cell Carcinoma of Head and Neck
PMC - PMC3775114
OTO - NOTNLM
OT  - Hep-2 cell
OT  - LSCC.
OT  - S100A11
OT  - migration
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2013/09/21 06:00
MHDA- 2014/04/12 06:00
PMCR- 2013/01/01
CRDT- 2013/09/19 06:00
PHST- 2013/01/30 00:00 [received]
PHST- 2013/08/12 00:00 [accepted]
PHST- 2013/09/19 06:00 [entrez]
PHST- 2013/09/21 06:00 [pubmed]
PHST- 2014/04/12 06:00 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - ijmsv10p1552 [pii]
AID - 10.7150/ijms.5986 [doi]
PST - epublish
SO  - Int J Med Sci. 2013 Sep 6;10(11):1552-9. doi: 10.7150/ijms.5986. eCollection 
      2013.