PMID- 24047701
OWN - NLM
STAT- MEDLINE
DCOM- 20131216
LR  - 20230216
IS  - 1541-6100 (Electronic)
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 143
IP  - 11
DP  - 2013 Nov
TI  - Expression of the placental transcriptome in maternal nutrient reduction in 
      baboons is dependent on fetal sex.
PG  - 1698-708
LID - 10.3945/jn.112.172148 [doi]
AB  - Maternal undernutrition increases the risk of perinatal complications and 
      predisposes offspring to obesity, diabetes, and cardiovascular disease later in 
      life. Emerging evidence suggests that changes in placental function play a role 
      in linking altered maternal nutrition in pregnancy to the subsequent development 
      of adult disease. The susceptibility for disease in response to an adverse 
      intrauterine environment differs distinctly between boys and girls, with girls 
      typically having better outcomes. Here, we tested the hypothesis that regulation 
      of the placental transcriptome by maternal nutrient reduction (NR) is dependent 
      on fetal sex. We used a nonhuman primate model of NR in which maternal global 
      food intake was reduced by 30% in baboons starting at gestational day (GD) 30. At 
      GD 165 (term = GD 183), placental genome expression profiling of 6 control (n = 3 
      females, 3 males) and 6 nutrient restricted (n = 3 females, 3 males) fetuses was 
      carried out followed by bioinformatic analysis. Surprisingly, there was no 
      coordinated placental molecular response to decreased nutrient availability when 
      analyzing the data without accounting for fetal sex. In contrast, female 
      placentas exhibited a highly coordinated response that included upregulation of 
      genes in networks, pathways, and functional groups related to programmed cell 
      death and downregulation of genes in networks, pathways, and functional groups 
      associated with cell proliferation. These changes were not apparent in the male 
      placentas. Our data support the concept that female placentas initiate complex 
      adaptive responses to an adverse intrauterine environment, which may contribute 
      to increased survival and better pregnancy outcomes in girls.
FAU - Cox, Laura A
AU  - Cox LA
AD  - Department of Genetics.
FAU - Li, Cun
AU  - Li C
FAU - Glenn, Jeremy P
AU  - Glenn JP
FAU - Lange, Kenneth
AU  - Lange K
FAU - Spradling, Kimberly D
AU  - Spradling KD
FAU - Nathanielsz, Peter W
AU  - Nathanielsz PW
FAU - Jansson, Thomas
AU  - Jansson T
LA  - eng
GR  - P01 HD021350/HD/NICHD NIH HHS/United States
GR  - P51 OD011133/OD/NIH HHS/United States
GR  - C06 RR 1 C06 RR013556/RR/NCRR NIH HHS/United States
GR  - 1 C06 RR017515/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130918
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (bcl-2-Associated X Protein)
RN  - EC 3.4.22.- (Caspase 3)
SB  - IM
MH  - Animals
MH  - Caspase 3/genetics/metabolism
MH  - Female
MH  - Immunohistochemistry
MH  - Male
MH  - *Maternal Nutritional Physiological Phenomena
MH  - Papio/*embryology/*metabolism
MH  - Placenta/*metabolism
MH  - Pregnancy
MH  - Pregnancy, Animal/*metabolism
MH  - Reproducibility of Results
MH  - Sex Factors
MH  - *Transcriptome
MH  - bcl-2-Associated X Protein/genetics/metabolism
PMC - PMC3796342
COIS- Author disclosures: L. A. Cox, C. Li, J. P. Glenn, K. Lange, K. D. Spradling, P. 
      W. Nathanielsz, and T. Jansson, no conflicts of interest.
EDAT- 2013/09/21 06:00
MHDA- 2013/12/18 06:00
PMCR- 2014/11/01
CRDT- 2013/09/20 06:00
PHST- 2013/09/20 06:00 [entrez]
PHST- 2013/09/21 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
PHST- 2014/11/01 00:00 [pmc-release]
AID - S0022-3166(22)01335-9 [pii]
AID - 172148 [pii]
AID - 10.3945/jn.112.172148 [doi]
PST - ppublish
SO  - J Nutr. 2013 Nov;143(11):1698-708. doi: 10.3945/jn.112.172148. Epub 2013 Sep 18.