PMID- 24047966
OWN - NLM
STAT- MEDLINE
DCOM- 20131113
LR  - 20221207
IS  - 1944-7884 (Electronic)
IS  - 1525-4135 (Print)
IS  - 1525-4135 (Linking)
VI  - 64
IP  - 2
DP  - 2013 Oct 1
TI  - Single-nucleotide polymorphisms in TrkB and risk for depression: findings from 
      the women's interagency HIV study.
PG  - 138-41
LID - 10.1097/QAI.0b013e3182a468e9 [doi]
AB  - Individuals infected with HIV type 1 are more likely than noninfected individuals 
      to develop depression. HIV lowers brain-derived neurotrophic factor (BDNF), a 
      neurotrophic factor whose receptors play a crucial role in the pathophysiology of 
      depression. Therefore, we examined whether a single-nucleotide polymorphism in 
      the BDNF gene (rs56164415) and related receptors TrkB (rs1212171) and p75 
      (rs2072446) were associated with depression in HIV-infected individuals. A total 
      of 1365 HIV-positive and 371 HIV-negative female subjects were included. The 
      distribution of alleles was analyzed independently in African Americans 
      (non-Hispanic) and Caucasians (non-Hispanic). We have found that the absence of 
      depressive symptoms in HIV-positive subjects is associated with a genetic 
      variation of the TrkB but not with BDNF or p75 genes. This mutation explains 0.8% 
      and 4.4% of the variability for the absence of depression in African Americans 
      and Caucasians, respectively.
FAU - Avdoshina, Valeriya
AU  - Avdoshina V
AD  - Departments of *Neuroscience and daggerMedicine, Georgetown University Medical Center, 
      Washington, DC; double daggerDepartments of Medicine and Epidemiology & Population Health, 
      Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY; 
       section signDepartments of Medicine, Stroger Hospital and Rush University, Chicago, IL; 
       ||Departments of Neurology and Pathology, SUNY Downstate Medical Center, Brooklyn, 
      NY;  paragraph signDepartment of Preventive Medicine, Keck School of Medicine, University of 
      Southern California, Los Angeles, CA; #Department of Epidemiology, Johns Hopkins 
      Bloomberg School of Public Health, Baltimore, MD; Departments of **Neurology; 
      daggerdaggerBiostatistics, Bioinformatics, and Biomathematics; double daggerdouble daggerPsychiatry, Georgetown 
      University Medical Center, Washington, DC; and  section sign section signCollaborative for Research on 
      Outcomes and Metrics, Department of Neurology, Georgetown University Medical 
      Center, Washington, DC.
FAU - Mocchetti, Italo
AU  - Mocchetti I
FAU - Liu, Chenglong
AU  - Liu C
FAU - Young, Mary A
AU  - Young MA
FAU - Anastos, Kathryn
AU  - Anastos K
FAU - Cohen, Mardge
AU  - Cohen M
FAU - Crystal, Howard
AU  - Crystal H
FAU - Pearce, Celeste L
AU  - Pearce CL
FAU - Golub, Elizabeth T
AU  - Golub ET
FAU - Tractenberg, Rochelle E
AU  - Tractenberg RE
LA  - eng
GR  - R01 DA026174/DA/NIDA NIH HHS/United States
GR  - U01-AI-42590/AI/NIAID NIH HHS/United States
GR  - U01 AI031834/AI/NIAID NIH HHS/United States
GR  - U01 AI035004/AI/NIAID NIH HHS/United States
GR  - U01-HD-32632/HD/NICHD NIH HHS/United States
GR  - U01-AI-34994/AI/NIAID NIH HHS/United States
GR  - P01 AI082971/AI/NIAID NIH HHS/United States
GR  - U01-AI-35004/AI/NIAID NIH HHS/United States
GR  - U01-AI-31834/AI/NIAID NIH HHS/United States
GR  - U01 AI034994/AI/NIAID NIH HHS/United States
GR  - R01 NS079172/NS/NINDS NIH HHS/United States
GR  - U01-AI-34993/AI/NIAID NIH HHS/United States
GR  - R25 MH080661/MH/NIMH NIH HHS/United States
GR  - UL1 RR024131/RR/NCRR NIH HHS/United States
GR  - U01 AI034989/AI/NIAID NIH HHS/United States
GR  - U01 AI034993/AI/NIAID NIH HHS/United States
GR  - 1R01-DA026174/DA/NIDA NIH HHS/United States
GR  - U01-AI-34989/AI/NIAID NIH HHS/United States
GR  - U01 HD032632/HD/NICHD NIH HHS/United States
GR  - U01 AI042590/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (NGFR protein, human)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Black or African American/genetics
MH  - Alleles
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Depressive Disorder/*genetics
MH  - Female
MH  - *Genetic Association Studies
MH  - Genotype
MH  - HIV Infections/*complications
MH  - Humans
MH  - Middle Aged
MH  - Nerve Tissue Proteins/genetics/metabolism
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Receptor, trkB/*genetics/metabolism
MH  - Receptors, Nerve Growth Factor/genetics/metabolism
MH  - Risk Factors
MH  - White People/genetics
MH  - Women's Health
PMC - PMC3780967
MID - NIHMS514701
EDAT- 2013/09/21 06:00
MHDA- 2013/11/14 06:00
PMCR- 2014/10/01
CRDT- 2013/09/20 06:00
PHST- 2013/09/20 06:00 [entrez]
PHST- 2013/09/21 06:00 [pubmed]
PHST- 2013/11/14 06:00 [medline]
PHST- 2014/10/01 00:00 [pmc-release]
AID - 00126334-201310010-00004 [pii]
AID - 10.1097/QAI.0b013e3182a468e9 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2013 Oct 1;64(2):138-41. doi: 
      10.1097/QAI.0b013e3182a468e9.