PMID- 24048741
OWN - NLM
STAT- MEDLINE
DCOM- 20141006
LR  - 20220317
IS  - 1559-1166 (Electronic)
IS  - 0895-8696 (Linking)
VI  - 52
IP  - 2
DP  - 2014 Feb
TI  - Update on therapeutic mechanism for bone marrow stromal cells in ischemic stroke.
PG  - 177-85
LID - 10.1007/s12031-013-0119-0 [doi]
AB  - Cerebral ischemia is a major cause of morbidity and mortality in the aged 
      population, as well as a tremendous burden on the healthcare system. Despite 
      timely treatment with thrombolysis and percutaneous intravascular interventions, 
      many patients are often left with irreversible neurological deficits. Bone marrow 
      stromal cells (BMSCs), also referred to as mesenchymal stem cells (MSCs), are a 
      type of nonhematopoietic stem cells which exists in bone marrow mesh, with the 
      potential to self-renew. Unlike cells in the central nervous system, BMSCs 
      differentiate not only into mesodermal cells, but also endodermal and ectodermal 
      cells. Moreover, it has been reported that BMSCs develop into cells with neural 
      and vascular markers and play a role in recovery from ischemic stroke. These 
      findings have fuelled excitement in regenerative medicine for neurological 
      diseases, especially for ischemic stroke. There is now preclinical evidence to 
      suggest that BMSCs grafted into the brain of ischemic models abrogate 
      neurological deficits. Based on the overwhelming evidence from animal studies as 
      well as in clinical trials, BMSC transplantation is considered a promising 
      strategy for treatment of ischemic stroke. The goal of this review is to present 
      an integrated consideration of molecular mechanisms in a chronological fashion 
      and discuss an optimal BMSC delivery route for ischemic stroke.
FAU - Wan, Huan
AU  - Wan H
AD  - Department of Neurology, First Hospital and Clinical College, Harbin Medical 
      University, Room 501, Building 3, 23 Youzheng, Harbin, 150001, China.
FAU - Li, Fangqin
AU  - Li F
FAU - Zhu, Lei
AU  - Zhu L
FAU - Wang, Jing
AU  - Wang J
FAU - Yang, Zizhen
AU  - Yang Z
FAU - Pan, Yujun
AU  - Pan Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130919
PL  - United States
TA  - J Mol Neurosci
JT  - Journal of molecular neuroscience : MN
JID - 9002991
SB  - IM
MH  - Animals
MH  - Brain Ischemia/*therapy
MH  - Humans
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/cytology/metabolism
MH  - Stroke/*therapy
EDAT- 2013/09/21 06:00
MHDA- 2014/10/07 06:00
CRDT- 2013/09/20 06:00
PHST- 2013/07/11 00:00 [received]
PHST- 2013/09/09 00:00 [accepted]
PHST- 2013/09/20 06:00 [entrez]
PHST- 2013/09/21 06:00 [pubmed]
PHST- 2014/10/07 06:00 [medline]
AID - 10.1007/s12031-013-0119-0 [doi]
PST - ppublish
SO  - J Mol Neurosci. 2014 Feb;52(2):177-85. doi: 10.1007/s12031-013-0119-0. Epub 2013 
      Sep 19.