PMID- 24049207
OWN - PIP
STAT- PubMed-not-MEDLINE
DCOM- 20130919
LR  - 20220317
IS  - 0019-5545 (Print)
IS  - 1998-3794 (Electronic)
IS  - 0019-5545 (Linking)
VI  - 55
IP  - Suppl 3
DP  - 2013 Jul
TI  - Low serum brain derived neurotrophic factor in non-suicidal out-patients with 
      depression: Relation to depression scores.
PG  - S397-9
LID - 10.4103/0019-5545.116311 [doi]
AB  - CONTEXT: Low brain-derived neurotrophic factor (BDNF) has been implicated in the 
      pathophysiology of depression. The relation between BDNF and severity of 
      depression has been investigated. AIMS: In this study, we aimed to measured serum 
      BDNF levels in never-treated non-suicidal out-patients with depression and relate 
      this to the severity of depression. SETTINGS AND DESIGN: This study was conducted 
      in an out-patient setting in a tertiary care psychiatric hospital on consenting 
      depressed patients. MATERIALS AND METHODS: Forty three (19 females) 
      antidepressant-naive out-patients with depression, aged between 18 and 55 years 
      and 24 (13 females) age-matched healthy volunteers gave consent for the study. 
      Serum BDNF levels were assayed by using the sandwich enzyme-linked immunosorbent 
      assay method on morning serum samples before starting treatment. These were 
      compared between patients and controls using independent sample t-test. Pearson's 
      correlation coefficient was used to assess the association between baseline BDNF 
      and Hamilton depression rating scale (HDRS). RESULTS: Serum BDNF was 
      significantly lower in patients with depression (mean+/-standard deviation 
      (SD)=18.59+/-4.9 ng/ml) than in healthy volunteers (mean+/-SD=23.6+/-5.6 ng/ml; 
      P=0.001). There was a significant negative correlation between the HDRS total 
      scores and BDNF levels (P=0.04), indicating that more severely depressed patients 
      had lower BDNF scores. CONCLUSIONS: Serum BDNF level is lower in non-suicidal 
      out-patients with depression. The inverse correlation between ratings of 
      depression and BDNF levels suggests possible relationship between depression, 
      (role of illness on) BDNF levels and neuroplasticity thereof.
FAU - Varambally, S
AU  - Varambally S
AD  - Department of Psychiatry, National Institute of Mental Health and Neurosciences, 
      Bangalore, Karnataka, India.
FAU - Naveen, G H
AU  - Naveen GH
FAU - Rao, M G
AU  - Rao MG
FAU - Thirthalli, J
AU  - Thirthalli J
FAU - Sharma, R
AU  - Sharma R
FAU - Christopher, R
AU  - Christopher R
FAU - Gangadhar, B N
AU  - Gangadhar BN
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Psychiatry
JT  - Indian journal of psychiatry
JID - 0013255
PMC - PMC3768220
OTO - NOTNLM
OT  - Brain derived neurotrophic factor
OT  - depression
OT  - hamilton depression rating scale
COIS- Conflict of Interest: None declared.
EDAT- 2013/09/21 06:00
MHDA- 2013/09/21 06:01
PMCR- 2013/07/01
CRDT- 2013/09/20 06:00
PHST- 2013/09/20 06:00 [entrez]
PHST- 2013/09/21 06:00 [pubmed]
PHST- 2013/09/21 06:01 [medline]
PHST- 2013/07/01 00:00 [pmc-release]
AID - IJPsy-55-397 [pii]
AID - 10.4103/0019-5545.116311 [doi]
PST - ppublish
SO  - Indian J Psychiatry. 2013 Jul;55(Suppl 3):S397-9. doi: 10.4103/0019-5545.116311.