PMID- 24049277
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130919
LR  - 20211021
IS  - 0971-4065 (Print)
IS  - 1998-3662 (Electronic)
IS  - 0971-4065 (Linking)
VI  - 23
IP  - 5
DP  - 2013 Sep
TI  - An unusual cause of gross hematuria and renal dysfunction in a young male.
PG  - 371-4
LID - 10.4103/0971-4065.116322 [doi]
AB  - Monoclonal immunoglobulin deposition disease (MIDD) is an uncommon disease with a 
      peak incidence between the 5(th) and 6(th) decades of life. It is characterized 
      by non-fibrillar, Congo red negative deposition of monoclonal immunoglobulins in 
      various organs, including in the kidneys. MIDD can be of three types depending on 
      the composition of the deposits, and includes light chain deposition disease 
      (LCDD), heavy chain deposition disease and light and heavy chain deposition 
      disease, of which LCDD is the most common. Renal involvement is a universal 
      finding in MIDD, and is in the form of renal insufficiency, microscopic hematuria 
      and nephrotic range proteinuria. Gross hematuria is a rare occurrence. Renal 
      biopsy usually shows nodular sclerosing glomerulopathy on light microscopy and 
      diffuse linear staining of glomerular and tubular basement membrane on 
      immunofluorescence microscopy. We report a young male who presented with rapidly 
      progressive renal failure and gross hematuria and was diagnosed as LCDD with 
      nodular glomerulopathy and crescents on renal biopsy.
FAU - Rathi, M
AU  - Rathi M
AD  - Department of Nephrology, Post Graduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Ramachandran, R
AU  - Ramachandran R
FAU - Kohli, H S
AU  - Kohli HS
FAU - Nada, R
AU  - Nada R
FAU - Jha, V
AU  - Jha V
FAU - Sakhuja, V
AU  - Sakhuja V
LA  - eng
PT  - Case Reports
PL  - India
TA  - Indian J Nephrol
JT  - Indian journal of nephrology
JID - 8914356
PMC - PMC3764715
OTO - NOTNLM
OT  - Monoclonal immunoglobulin deposition disease
OT  - multiple myeloma
OT  - rapidly progressive renal failure
COIS- Conflict of Interest: None declared.
EDAT- 2013/09/21 06:00
MHDA- 2013/09/21 06:01
PMCR- 2013/09/01
CRDT- 2013/09/20 06:00
PHST- 2013/09/20 06:00 [entrez]
PHST- 2013/09/21 06:00 [pubmed]
PHST- 2013/09/21 06:01 [medline]
PHST- 2013/09/01 00:00 [pmc-release]
AID - IJN-23-371 [pii]
AID - 10.4103/0971-4065.116322 [doi]
PST - ppublish
SO  - Indian J Nephrol. 2013 Sep;23(5):371-4. doi: 10.4103/0971-4065.116322.