PMID- 24049737
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130919
LR  - 20211021
IS  - 2212-8778 (Print)
IS  - 2212-8778 (Electronic)
IS  - 2212-8778 (Linking)
VI  - 2
IP  - 3
DP  - 2013
TI  - The sexually dimorphic role of adipose and adipocyte estrogen receptors in 
      modulating adipose tissue expansion, inflammation, and fibrosis.
PG  - 227-42
LID - 10.1016/j.molmet.2013.05.006 [doi]
AB  - Our data demonstrate that estrogens, estrogen receptor-alpha (ERalpha), and estrogen 
      receptor-beta (ERbeta) regulate adipose tissue distribution, inflammation, fibrosis, 
      and glucose homeostasis, by determining that alphaERKO mice have increased adipose 
      tissue inflammation and fibrosis prior to obesity onset. Selective deletion of 
      adipose tissue ERalpha in adult mice using a novel viral vector technology 
      recapitulated the findings in the total body ERalpha null mice. Generation of a novel 
      mouse model, lacking ERalpha specifically from adipocytes (AdipoERalpha), demonstrated 
      increased markers of fibrosis and inflammation, especially in the males. 
      Additionally, we found that the beneficial effects of estrogens on adipose tissue 
      require adipocyte ERalpha. Lastly, we determined the role of ERbeta in regulating 
      inflammation and fibrosis, by breeding the AdipoERalpha into the betaERKO background and 
      found that in the absence of adipocyte ERalpha, ERbeta has a protective role. These data 
      suggest that adipose tissue and adipocyte ERalpha protects against adiposity, 
      inflammation, and fibrosis in both males and females.
FAU - Davis, Kathryn E
AU  - Davis KE
AD  - Touchstone Diabetes Center, Department of Internal Medicine, University of Texas 
      Southwestern Medical Center, 5323 Harry Hines Blvd., K5.252, Dallas, TX 
      75390-8854, USA.
FAU - D Neinast, Michael
AU  - D Neinast M
FAU - Sun, Kai
AU  - Sun K
FAU - M Skiles, William
AU  - M Skiles W
FAU - D Bills, Jessica
AU  - D Bills J
FAU - A Zehr, Jordan
AU  - A Zehr J
FAU - Zeve, Daniel
AU  - Zeve D
FAU - D Hahner, Lisa
AU  - D Hahner L
FAU - W Cox, Derek
AU  - W Cox D
FAU - M Gent, Lana
AU  - M Gent L
FAU - Xu, Yong
AU  - Xu Y
FAU - V Wang, Zhao
AU  - V Wang Z
FAU - A Khan, Sohaib
AU  - A Khan S
FAU - Clegg, Deborah J
AU  - Clegg DJ
LA  - eng
GR  - P01 DK088761/DK/NIDDK NIH HHS/United States
GR  - R01 DK088220/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20130604
PL  - Germany
TA  - Mol Metab
JT  - Molecular metabolism
JID - 101605730
PMC - PMC3773827
OTO - NOTNLM
OT  - BAT, brown adipose tissue
OT  - ERalpha, estrogen receptor alpha
OT  - ERbeta, estrogen receptor beta
OT  - Estrogen receptor alpha (ERalpha)
OT  - Fibrosis
OT  - Inflammation
OT  - WAT, white adipose tissue
OT  - White adipose tissue (WAT)
EDAT- 2013/09/21 06:00
MHDA- 2013/09/21 06:01
PMCR- 2013/06/04
CRDT- 2013/09/20 06:00
PHST- 2013/04/26 00:00 [received]
PHST- 2013/05/22 00:00 [revised]
PHST- 2013/05/27 00:00 [accepted]
PHST- 2013/09/20 06:00 [entrez]
PHST- 2013/09/21 06:00 [pubmed]
PHST- 2013/09/21 06:01 [medline]
PHST- 2013/06/04 00:00 [pmc-release]
AID - S2212-8778(13)00053-7 [pii]
AID - 10.1016/j.molmet.2013.05.006 [doi]
PST - epublish
SO  - Mol Metab. 2013 Jun 4;2(3):227-42. doi: 10.1016/j.molmet.2013.05.006. eCollection 
      2013.