PMID- 24051499
OWN - NLM
STAT- MEDLINE
DCOM- 20140626
LR  - 20211203
IS  - 1423-0224 (Electronic)
IS  - 0302-282X (Linking)
VI  - 68
IP  - 3
DP  - 2013
TI  - Translational findings on brain-derived neurotrophic factor and anxiety: 
      contributions from basic research to clinical practice.
PG  - 129-38
LID - 10.1159/000353269 [doi]
AB  - BACKGROUND/AIMS: Anxious responses are evolutionarily adaptive, but excessive 
      fear can become disabling and lead to anxiety disorders. Translational models of 
      anxiety might be useful sources for understanding the neurobiology of fear and 
      anxiety and can contribute to future proposals of therapeutic intervention for 
      the disorders studied. Brain-derived neurotrophic factor (BDNF), which is known 
      for its importance on neuroplasticity and contextual memory, has emerged as a 
      relevant element for emotional memory. Recent studies show that the Val(66)Met 
      BDNF polymorphism correlates with various psychiatric disorders, including 
      anxiety, but there are several differences between experimental and clinical 
      studies. METHODS: In this work, we review the literature focused on the BDNF 
      Val(66)Met polymorphism and anxiety, and discuss biological findings from animal 
      models to clinical studies. RESULTS: As occurs with other psychiatric disorders, 
      anxiety correlates with anatomical, behavioral and physiological changes related 
      to the BDNF polymorphism. In animal studies, it has been shown that a significant 
      decrease in regulated secretion from both BDNFVal/Met and BDNFMet/Met neurons 
      represented a significant decrease in available BDNF. CONCLUSION: These studies 
      suggest that developing pharmacological strategies facilitating the release of 
      BDNF from synapses or prolongation of the half-life of secreted BDNF may improve 
      the therapeutic responses of humans expressing the BDNF polymorphism.
CI  - Copyright (c) 2013 S. Karger AG, Basel.
FAU - Domingos da Silveira da Luz, Anna Claudia
AU  - Domingos da Silveira da Luz AC
AD  - Laboratory of Panic and Respiration, Institute of Psychiatry, Universidade 
      Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
FAU - Pereira Dias, Gisele
AU  - Pereira Dias G
FAU - do Nascimento Bevilaqua, Mario Cesar
AU  - do Nascimento Bevilaqua MC
FAU - Cocks, Graham
AU  - Cocks G
FAU - Gardino, Patricia Franca
AU  - Gardino PF
FAU - Thuret, Sandrine
AU  - Thuret S
FAU - Nardi, Antonio Egidio
AU  - Nardi AE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130913
PL  - Switzerland
TA  - Neuropsychobiology
JT  - Neuropsychobiology
JID - 7512895
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Anxiety/*genetics/physiopathology
MH  - Brain-Derived Neurotrophic Factor/*genetics/physiology
MH  - Humans
MH  - Memory/physiology
MH  - Mice
MH  - *Polymorphism, Genetic
MH  - Rats
MH  - Translational Research, Biomedical
EDAT- 2013/09/21 06:00
MHDA- 2014/06/27 06:00
CRDT- 2013/09/21 06:00
PHST- 2012/11/15 00:00 [received]
PHST- 2013/05/27 00:00 [accepted]
PHST- 2013/09/21 06:00 [entrez]
PHST- 2013/09/21 06:00 [pubmed]
PHST- 2014/06/27 06:00 [medline]
AID - 000353269 [pii]
AID - 10.1159/000353269 [doi]
PST - ppublish
SO  - Neuropsychobiology. 2013;68(3):129-38. doi: 10.1159/000353269. Epub 2013 Sep 13.