PMID- 24051673 OWN - NLM STAT- MEDLINE DCOM- 20140828 LR - 20131216 IS - 1421-9913 (Electronic) IS - 0014-3022 (Linking) VI - 70 IP - 5-6 DP - 2013 TI - No association between brain-derived neurotrophic factor G196A polymorphism and clinical features of Parkinson's disease. PG - 257-62 LID - 10.1159/000352033 [doi] AB - AIMS: To investigate association of the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene with clinical features in Serbian patients with Parkinson's disease (PD). METHODS: The study comprised 177 consecutive PD patients. A comprehensive set of clinical scales was applied in all patients. The controls (n=366) were recruited among students. Single nucleotide polymorphisms (SNPs; rs6265) were analyzed using TaqMan assays. RESULTS: PD patients (118 males) were aged 58.9+/-10.9 years, with a mean age at onset of 49.0+/-11.2 years. PD patients and controls had a similar distribution of genotypes and allele frequencies. The presence of the Met allele did not influence the clinical characteristics of PD patients (age at onset, family history, gender, disease duration, form of the disease, initial symptoms, cognitive abilities, depression, anxiety, disease severity, severity of motor and prevalence of nonmotor symptoms, and development of motor complications). CONCLUSION: Overall, the Val66Met polymorphism did not modify the clinical features in PD patients. CI - Copyright (c) 2013 S. Karger AG, Basel. FAU - Svetel, Marina AU - Svetel M AD - Clinic of Neurology CCS, University of Belgrade, Belgrade, Serbia. FAU - Pekmezovic, Tatjana AU - Pekmezovic T FAU - Markovic, Vladana AU - Markovic V FAU - Novakovic, Ivana AU - Novakovic I FAU - Dobricic, Valerija AU - Dobricic V FAU - Djuric, Gordana AU - Djuric G FAU - Stefanova, Elka AU - Stefanova E FAU - Kostic, Vladimir AU - Kostic V LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20130917 PL - Switzerland TA - Eur Neurol JT - European neurology JID - 0150760 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Adult MH - Age of Onset MH - Aged MH - Brain-Derived Neurotrophic Factor/*genetics MH - Female MH - Gene Frequency MH - *Genetic Predisposition to Disease MH - Genotype MH - Humans MH - Male MH - Middle Aged MH - Parkinson Disease/*genetics MH - *Polymorphism, Single Nucleotide EDAT- 2013/09/21 06:00 MHDA- 2014/08/29 06:00 CRDT- 2013/09/21 06:00 PHST- 2013/02/15 00:00 [received] PHST- 2013/05/05 00:00 [accepted] PHST- 2013/09/21 06:00 [entrez] PHST- 2013/09/21 06:00 [pubmed] PHST- 2014/08/29 06:00 [medline] AID - 000352033 [pii] AID - 10.1159/000352033 [doi] PST - ppublish SO - Eur Neurol. 2013;70(5-6):257-62. doi: 10.1159/000352033. Epub 2013 Sep 17.