PMID- 24051980
OWN - NLM
STAT- MEDLINE
DCOM- 20140317
LR  - 20220318
IS  - 1420-9071 (Electronic)
IS  - 1420-682X (Print)
IS  - 1420-682X (Linking)
VI  - 71
IP  - 4
DP  - 2014 Feb
TI  - Monocyte chemoattractant protein-1 and the blood-brain barrier.
PG  - 683-97
LID - 10.1007/s00018-013-1459-1 [doi]
AB  - The blood-brain barrier (BBB) is a dynamic structure that maintains the 
      homeostasis of the brain and thus proper neurological functions. BBB compromise 
      has been found in many pathological conditions, including neuroinflammation. 
      Monocyte chemoattractant protein-1 (MCP1), a chemokine that is transiently and 
      significantly up-regulated during inflammation, is able to disrupt the integrity 
      of BBB and modulate the progression of various diseases, including excitotoxic 
      injury and hemorrhage. In this review, we first introduce the biochemistry and 
      biology of MCP1, and then summarize the effects of MCP1 on BBB integrity as well 
      as individual BBB components.
FAU - Yao, Yao
AU  - Yao Y
AD  - Program in Molecular and Cellular Pharmacology, Department of Pharmacological 
      Sciences, BST8-192, Stony Brook University, Stony Brook, NY, 11794-8651, USA.
FAU - Tsirka, Stella E
AU  - Tsirka SE
LA  - eng
GR  - R01 NS042168/NS/NINDS NIH HHS/United States
GR  - R01NS42168/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130920
PL  - Switzerland
TA  - Cell Mol Life Sci
JT  - Cellular and molecular life sciences : CMLS
JID - 9705402
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Animals
MH  - Astrocytes/immunology/metabolism
MH  - Blood-Brain Barrier/*cytology/*immunology/metabolism
MH  - Chemokine CCL2/*immunology/metabolism
MH  - Endothelial Cells/immunology/metabolism
MH  - Humans
MH  - Microglia/immunology/metabolism
MH  - Neurons/immunology/metabolism
MH  - Pericytes/immunology/metabolism
PMC - PMC3946874
MID - NIHMS526170
EDAT- 2013/09/21 06:00
MHDA- 2014/03/19 06:00
PMCR- 2015/02/01
CRDT- 2013/09/21 06:00
PHST- 2013/05/18 00:00 [received]
PHST- 2013/08/19 00:00 [accepted]
PHST- 2013/07/20 00:00 [revised]
PHST- 2013/09/21 06:00 [entrez]
PHST- 2013/09/21 06:00 [pubmed]
PHST- 2014/03/19 06:00 [medline]
PHST- 2015/02/01 00:00 [pmc-release]
AID - 10.1007/s00018-013-1459-1 [doi]
PST - ppublish
SO  - Cell Mol Life Sci. 2014 Feb;71(4):683-97. doi: 10.1007/s00018-013-1459-1. Epub 
      2013 Sep 20.