PMID- 2405291
OWN - NLM
STAT- MEDLINE
DCOM- 19900315
LR  - 20190514
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 40
IP  - 2
DP  - 1990 Feb
TI  - High-dose intravenous immunoglobulin treatment in chronic inflammatory 
      demyelinating polyneuropathy: a double-blind, placebo-controlled, crossover 
      study.
PG  - 209-12
AB  - We discontinued high-dose intravenous immunoglobulin treatment (IVIg) in 7 
      patients with chronic inflammatory demyelinating polyneuropathy (CIDP) who seemed 
      to have responded to IVIg. After discontinuation of treatment, all 7 patients 
      deteriorated. We then randomized the patients to IVIg or placebo (albumin) 
      treatment in a double-blind crossover study. The clinical condition of all 
      patients improved after IVIg and did not improve after placebo treatment. The 
      mean time lapse from the end of the trial treatment to the occurrence of 
      deterioration was 6.4 weeks after treatment with IVIg and 1.3 weeks after 
      treatment with placebo. This selected group of patients with CIDP had a 
      beneficial response to IVIg.
FAU - van Doorn, P A
AU  - van Doorn PA
AD  - Department of Neurology, University Hospital Rotterdam-Dijkzigt, The Netherlands.
FAU - Brand, A
AU  - Brand A
FAU - Strengers, P F
AU  - Strengers PF
FAU - Meulstee, J
AU  - Meulstee J
FAU - Vermeulen, M
AU  - Vermeulen M
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (Immunoglobulins)
SB  - IM
CIN - Neurology. 1990 Feb;40(2):327-8. PMID: 2300259
MH  - Adult
MH  - Child
MH  - Chronic Disease
MH  - Demyelinating Diseases/physiopathology/*therapy
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - *Immunization, Passive
MH  - Immunoglobulins/*administration & dosage
MH  - Infusions, Intravenous
MH  - Male
MH  - Middle Aged
MH  - Neural Conduction
MH  - Polyneuropathies/physiopathology/*therapy
MH  - Polyradiculoneuropathy/physiopathology/therapy
MH  - Randomized Controlled Trials as Topic
EDAT- 1990/02/01 00:00
MHDA- 1990/02/01 00:01
CRDT- 1990/02/01 00:00
PHST- 1990/02/01 00:00 [pubmed]
PHST- 1990/02/01 00:01 [medline]
PHST- 1990/02/01 00:00 [entrez]
AID - 10.1212/wnl.40.2.209 [doi]
PST - ppublish
SO  - Neurology. 1990 Feb;40(2):209-12. doi: 10.1212/wnl.40.2.209.