PMID- 2405341
OWN - NLM
STAT- MEDLINE
DCOM- 19900315
LR  - 20220330
IS  - 8755-6863 (Print)
IS  - 1099-0496 (Linking)
VI  - 8
IP  - 1
DP  - 1990
TI  - Correlation of IgE antibody titer to Aspergillus fumigatus with decreased lung 
      function in cystic fibrosis.
PG  - 12-5
AB  - Obstructive pulmonary disease is a typical feature of cystic fibrosis (CF) and is 
      often associated with bronchial hyperreactivity. Positive skin-test reactions to 
      Aspergillus fumigatus antigens are frequently seen even in nonatopic patients 
      with CF. Full-fledged allergic bronchopulmonary aspergillosis (ABPA) has been 
      estimated to occur in 10% of patients with CF. The relationship between lung 
      function and presence of IgE antibodies to Aspergillus antigens in patients 
      without ABPA is not clear. In 148 outpatients with CF (aged 6-34 years) specific 
      immunoglobulin E (IgE) to Aspergillus fumigatus antigens, basic lung-function 
      parameters, and bronchial response to salbutamol were measured. Multiple 
      regression was performed for age, weight as percentile for actual height 
      (indicating general condition), and Aspergillus RAST. Aspergillus IgE was present 
      in 46% of patients; 19% had RAST class 3 or 4. Independent negative correlations 
      of Aspergillus RAST with FEV1, FEF50%, FEF25%, RV, Chrispin Norman score, and 
      sRaw (P less than 0.05) were found. Bronchodilator sensitivity did not correlate 
      significantly with age and weight percentile. However, Aspergillus RAST did 
      correlate significantly with bronchodilator response measured by sRaw (P less 
      than 0.05). High titers of Aspergillus RAST might serve as a selective criterion 
      for patients to be included in future studies evaluating broncholytic or 
      antiphlogistic therapies.
FAU - Nicolai, T
AU  - Nicolai T
AD  - Universitatskinderklinik Munchen, Federal Republic of Germany.
FAU - Arleth, S
AU  - Arleth S
FAU - Spaeth, A
AU  - Spaeth A
FAU - Bertele-Harms, R M
AU  - Bertele-Harms RM
FAU - Harms, H K
AU  - Harms HK
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Pediatr Pulmonol
JT  - Pediatric pulmonology
JID - 8510590
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aspergillus fumigatus/*immunology
MH  - Child
MH  - Clinical Trials as Topic
MH  - Cystic Fibrosis/immunology/*physiopathology
MH  - Humans
MH  - Immunoglobulin E/*analysis
MH  - Lung/*physiopathology
MH  - Radioallergosorbent Test
MH  - Regression Analysis
MH  - Respiratory Function Tests
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 10.1002/ppul.1950080106 [doi]
PST - ppublish
SO  - Pediatr Pulmonol. 1990;8(1):12-5. doi: 10.1002/ppul.1950080106.