PMID- 24053559
OWN - NLM
STAT- MEDLINE
DCOM- 20140707
LR  - 20221207
IS  - 1945-0257 (Electronic)
IS  - 1945-0257 (Linking)
VI  - 17
IP  - 12
DP  - 2013 Dec
TI  - MCP-1-2518A>G polymorphism and myocardial infarction risk: a meta-analysis and 
      meta-regression.
PG  - 857-63
LID - 10.1089/gtmb.2013.0318 [doi]
AB  - OBJECTIVE: Monocyte chemoattractant protein-1 (MCP-1), a key chemokine in 
      atherosclerotic inflammation, plays an important role in the etiology of 
      myocardial infarction (MI). Emerging evidence has shown that the common 
      polymorphism (-2518A>G; rs1024611) in the MCP-1 gene may contribute to the risk 
      of MI, but individually published studies showed inconclusive results. This 
      meta-analysis aimed to derive a more precise estimation of the associations 
      between MCP-1-2518A>G polymorphism and susceptibility to MI. METHODS: A 
      literature search of PubMed, Embase, Web of Science, and China BioMedicine (CBM) 
      databases was conducted on articles published before May 15th, 2013. The crude 
      odds ratios with 95% confidence intervals were calculated. RESULTS: Eleven 
      case-control studies were included with a total 2325 MI patients and 6310 healthy 
      controls. The meta-analysis results indicated that MCP-1-2518A>G polymorphism was 
      associated with an increased risk of MI. In further subgroup analysis based on 
      ethnicity, there were significant associations between MCP-1-2518A>G polymorphism 
      and an increased risk of MI among Asian populations. However, no statistically 
      significant association was found among Caucasian populations. Univariate and 
      multivariate meta-regression analyses showed that ethnicity may be the major 
      source of heterogeneity. No publication bias was detected in this meta-analysis. 
      CONCLUSION: In conclusion, the current meta-analysis indicates that MCP-1-2518A>G 
      polymorphism may be a risk factor for MI, especially among Asian populations.
FAU - Mao, Bin
AU  - Mao B
AD  - 1 Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical 
      University , Beijing, People's Republic of China .
FAU - Zhang, Jianqun
AU  - Zhang J
FAU - Zhuo, Fengling
AU  - Zhuo F
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20130921
PL  - United States
TA  - Genet Test Mol Biomarkers
JT  - Genetic testing and molecular biomarkers
JID - 101494210
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Asian People
MH  - Chemokine CCL2/*genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - Myocardial Infarction/ethnology/*genetics
MH  - *Polymorphism, Genetic
MH  - PubMed
MH  - Risk Factors
MH  - White People
EDAT- 2013/09/24 06:00
MHDA- 2014/07/08 06:00
CRDT- 2013/09/24 06:00
PHST- 2013/09/24 06:00 [entrez]
PHST- 2013/09/24 06:00 [pubmed]
PHST- 2014/07/08 06:00 [medline]
AID - 10.1089/gtmb.2013.0318 [doi]
PST - ppublish
SO  - Genet Test Mol Biomarkers. 2013 Dec;17(12):857-63. doi: 10.1089/gtmb.2013.0318. 
      Epub 2013 Sep 21.